@article{3021329,
    title = "Fluorine substituted methoxyphenylalkyl amides as potent melatonin receptor agonists†",
    author = "Tsotinis, A. and Kompogennitaki, R. and Papanastasiou, I. and Garratt, P.J. and Bocianowska, A. and Sugden, D.",
    journal = "MedChemComm",
    year = "2019",
    pages = "460-464",
    publisher = "Royal Society of Chemistry",
    issn = "2040-2503, 2040-2511",
    doi = "10.1039/c8md00604k",
    keywords = "amide;  fluorine;  melatonin;  melatonin receptor agonist;  methoxyphenylalkyl amide derivative;  unclassified drug, Article;  bioassay;  chemical modification;  concentration response;  controlled study;  drug potency;  drug structure;  drug synthesis;  melanophore;  nonhuman;  priority journal;  reaction analysis;  structure activity relation;  Xenopus",
    abstract = "A series of fluorine substituted methoxyphenylalkyl amides were prepared with different orientations of the fluorine and methoxy groups with respect to the alkylamide side chain and with alkyl sides of differing lengths (n = 1-3). β-Dimethyl and α-methyl derivatives were also synthesised. The compounds were tested as melatonin agonists and antagonists using the pigment aggregation of Xenopus melanophores as the biological assay. A number of these compounds were potent melatonin agonists, the potency depending on the length of the alkyl chain, the orientation of the methoxy and fluorine substituents, the amide chain length and, for the ethyl side-chain analogues, the presence of β-substituents. © The Royal Society of Chemistry 2019"
}