@article{3021503,
    title = "Association study of the CTH 1364 G>T polymorphism with coronary artery disease in the Greek population",
    author = "Giannakopoulou, E. and Konstantinou, F. and Ragia, G. and Gerontitis, Z. and Tavridou, A. and Papapetropoulos, A. and Mikroulis, D. and Manolopoulos, V.G.",
    journal = "Drug Metabolism and Personalized Therapy",
    year = "2019",
    volume = "34",
    number = "1",
    publisher = "De Gruyter Mouton",
    issn = "2363-8907, 2363-8915",
    doi = "10.1515/dmpt-2018-0033",
    keywords = "glucose;  high density lipoprotein cholesterol;  low density lipoprotein cholesterol;  triacylglycerol;  cystathionine gamma lyase, adult;  aged;  Article;  case control study;  cholesterol blood level;  controlled study;  coronary artery bypass graft;  coronary artery disease;  DNA isolation;  DNA polymorphism;  female;  gene frequency;  genetic association study;  genetic variation;  genotype;  Greek (people);  human;  major clinical study;  male;  polymerase chain reaction;  restriction fragment length polymorphism;  coronary artery disease;  genetics;  Greece;  middle aged;  single nucleotide polymorphism, Aged;  Case-Control Studies;  Coronary Artery Disease;  Cystathionine gamma-Lyase;  Female;  Genotype;  Greece;  Humans;  Male;  Middle Aged;  Polymorphism, Single Nucleotide",
    abstract = "Cystathionine γ-lyase enzyme, which is encoded by the CTH gene, is responsible for hydrogen sulfide (H2S) production in the endothelium. The CTH 1364 G>T polymorphism may alter the CTH expression and H2S bioavailability, thus leading to atherosclerosis and coronary artery disease (CAD). We examined the potential association of the CTH 1364 G>T polymorphism with CAD. The CTH 1364 G>T polymorphism was determined in 178 coronary artery bypass grafting (CABG) patients and 156 non-atherosclerotic controls of Greek Caucasian origin using the PCR-RFLP method. No significant difference in the frequency of the CTH 1364 G>T genotypes (p = 0.281) and alleles (p = 0.265) was found between the CABG patients and controls. After conducting stratification according to sex, analysis showed a numerical difference in the CTH 1364 TT genotype frequency in female participants that did not reach statistical significance (16.3% and 8.5% in the CABG and controls, respectively, p = 0.26). The frequency of the CTH 1364 TT genotype between the male CABG patients and controls did not differ (p = 0.507). The CTH 1364 G>T polymorphism was not associated with CAD in the studied population. However, interestingly, a higher - if not significantly so - CTH 1364 TT genotype frequency was present in female CABG patients compared with female controls. Larger studies are necessary to conclude on the potential overall or gender-driven association between CTH 1364 G>T gene polymorphism and CAD. © 2019 Walter de Gruyter GmbH, Berlin/Boston."
}