@article{3021820,
    title = "Associations between adiponectin gene variability, pro-inflammatory and angiogenetic markers: Implications for microvascular disease development in type 2 diabetes mellitus?",
    author = "Kollia, C. and Antonopoulos, A.S. and Siasos, G. and Konsola, T. and Oikonomou, E. and Gouliopoulos, N. and Tsigkou, V. and Papapanagiotou, A. and Kassi, E. and Tentolouris, N. and Katsiki, N. and Vavuranakis, M. and Papavassiliou, A.G. and Tousoulis, D.",
    journal = "Current Vascular Pharmacology",
    year = "2018",
    volume = "17",
    number = "2",
    pages = "204-208",
    publisher = "Bentham Science Publishers B.V.",
    issn = "1570-1611",
    doi = "10.2174/1570161116666180108113825",
    keywords = "adiponectin;  angiogenic protein;  C reactive protein;  hemoglobin A1c;  intercellular adhesion molecule 1;  interleukin 6;  vasculotropin;  adiponectin;  ADIPOQ protein, human;  autacoid;  biological marker;  C reactive protein;  ICAM1 protein, human;  IL6 protein, human;  intercellular adhesion molecule 1;  interleukin 6;  vasculotropin A;  VEGFA protein, human, aged;  Article;  body mass;  cholesterol blood level;  coronary artery disease;  disease course;  disease duration;  dyslipidemia;  enzyme linked immunosorbent assay;  family history;  female;  gene frequency;  genetic association;  genetic variability;  genotype;  human;  hypertension;  inflammation;  major clinical study;  male;  microangiopathy;  nephelometry;  non insulin dependent diabetes mellitus;  polymerase chain reaction;  risk factor;  single nucleotide polymorphism;  angiogenesis;  blood;  cross-sectional study;  diabetic angiopathy;  genetics;  non insulin dependent diabetes mellitus;  pathophysiology;  risk assessment;  single nucleotide polymorphism, Adiponectin;  Aged;  Biomarkers;  C-Reactive Protein;  Cross-Sectional Studies;  Diabetes Mellitus, Type 2;  Diabetic Angiopathies;  Female;  Humans;  Inflammation Mediators;  Intercellular Adhesion Molecule-1;  Interleukin-6;  Male;  Neovascularization, Physiologic;  Polymorphism, Single Nucleotide;  Risk Assessment;  Risk Factors;  Vascular Endothelial Growth Factor A",
    abstract = "Background: Adiponectin gene (ADIPOQ) variability may affect the risk for type 2 diabetes mellitus (T2DM) but it remains unclear whether it is involved in microvascular complications. Objective: To explore the impact of ADIPOQ variability on markers of inflammation and angiogenesis in T2DM. Methods: Overall, 220 consecutive T2DM patients from our outpatient diabetic clinic were genotyped for G276T (rs1501299) and T45G (rs2241766) single nucleotide polymorphisms of ADIPOQ gene. Serum levels of interleukin-6 (IL-6), intercellular adhesion molecule-1 (ICAM-1), vascular endothelial growth factor (VEGF) were measured by enzyme-linked immunosorbent assay and high sensitivity C-reactive protein (hsCRP) by immunonephelometry. Results: Homozygosity for the G allele on rs2241766 was associated with significantly lower serum VEGF and ICAM-1 levels compared with other genotype groups, but had no effect on IL-6. Genetic variability on rs1501299 was not associated with either VEGF or ICAM-1 levels, but T homozygotes for rs1501299 had significantly lower IL-6 concentrations compared with G carriers. Furthermore, the presence of the G allele on rs2241766 was associated with significantly lower HbA1c, whereas no associations were observed for both body mass index and hsCRP with either rs2241766 or rs1501299. Conclusion: Genetic variability on adiponectin gene was associated with serum levels of inflammatory and angiogenetic markers. Further research is required to elucidate the role of adiponectin in the development and/or progression of microvascular disease in T2DM patients. © 2019 Bentham Science Publishers."
}