@article{3021859,
    title = "Critical role of IL-8 targeting in gliomas",
    author = "Kosmopoulos, M. and Christofides, A. and Drekolias, D. and Zavras, P.D. and Gargalionis, A.N. and Piperi, C.",
    journal = "Current Medicinal Chemistry",
    year = "2018",
    volume = "25",
    number = "17",
    pages = "1954-1967",
    publisher = "Bentham Science Publishers B.V.",
    issn = "0929-8673",
    doi = "10.2174/0929867325666171129125712",
    keywords = "biological marker;  cediranib;  dehydroxymethylepoxyquinomicin;  interleukin 6;  interleukin 8;  transforming growth factor beta;  tumor necrosis factor;  antineoplastic agent;  IL8 protein, human;  interleukin 8;  tumor marker, angiogenesis;  astrocyte cell line;  cell migration;  chemoradiotherapy;  data base;  early diagnosis;  follow up;  glioblastoma;  glioma;  glioma cell;  human;  pathogenesis;  Review;  animal;  antagonists and inhibitors;  carcinogenesis;  cell motion;  chemically induced;  down regulation;  drug effect;  genetics;  glioma;  metabolism;  neovascularization (pathology), Animals;  Antineoplastic Agents;  Biomarkers, Tumor;  Carcinogenesis;  Cell Movement;  Down-Regulation;  Glioma;  Humans;  Interleukin-8;  Neovascularization, Pathologic",
    abstract = "Background: Glioma is a heterogeneous, highly complicated central nervous system (CNS) tumor with uncertain mechanism of initiation and progression, resulting in an unfavorable outcome. An extended network of cytokines is recognized as a major regulator of glioma pathogenesis, either promoting or inhibiting glioma progression based on their type and specificity. Interleukin-8 (IL-8) has been revealed as a critical regulator of CNS function and development with participation in many CNS disorders including gliomas. Objective: The aim of the present review is to address the role of IL-8 in glioma pathogenesis focusing on the implicated molecular pathways as well as on its potential targeting for glioma therapy. Methods and Results: PubMed-Medline, SCOPUS, and Google Scholar databases were searched for pre-clinical and clinical studies related to IL-8 implication in gliomagenesis and IL-8 targeting strategies for gliomas. Literature data indicate that IL-8 participates in glioma angiogenesis and cell migration and it can serve as a potential biomarker, for early diagnosis, follow-up and response to therapy. Conclusion: Several promising approaches that target directly or indirectly IL-8 effects in gliomas are currently in progress while more-in-depth studies are needed to validate its biomarker role and elucidate the underlying molecular mechanisms. © 2018 Bentham Science Publishers."
}