@article{3022280,
    title = "Chemical constituents from Cordia alliodora and C. colloccoca (Boraginaceae) and their biological activities",
    author = "Fouseki, M.M. and Damianakos, H. and Karikas, G.A. and Roussakis, C. and P.Gupta, M. and Chinou, I.",
    journal = "Fitoterapia",
    year = "2016",
    volume = "115",
    pages = "9-14",
    publisher = "Elsevier B.V.",
    issn = "0367-326X",
    doi = "10.1016/j.fitote.2016.09.004",
    keywords = "5 o [beta dextro apiofuranosyl (1-6) beta dextro glucopyranosyl] 1 isoindolinone;  afzelin;  allantoin;  amoxicillin;  amphotericin;  antibiotic agent;  antifungal agent;  canthoside c;  clavulanic acid;  cytotoxic agent;  flavonoid;  n 3 [2 (4 hydroxy 3 methoxyphenyl) 3 (hydroxymethyl) 7 methoxy 2,3 dihydro 1 benzofuran 5 yl]acryloylglycine;  n carbamoylputrescine;  netilmicin;  quercitrin;  rosmarinic acid;  unclassified drug;  afzelin;  indole derivative;  mannoside;  plant extract;  proanthocyanidin;  quercetin;  quercitrin, A549 cell line;  antibacterial activity;  antifungal activity;  antiproliferative activity;  Article;  bark;  Candida albicans;  Candida glabrata;  Candida tropicalis;  carbon nuclear magnetic resonance;  column chromatography;  controlled study;  Cordia;  Cordia alliodora;  Cordia colloccoca;  drug structure;  electrospray mass spectrometry;  Enterobacter cloacae;  Escherichia coli;  heteronuclear multiple bond correlation;  heteronuclear multiple quantum coherence;  human;  human cell;  IC50;  in vitro study;  Klebsiella pneumoniae;  lung carcinoma;  minimum inhibitory concentration;  nonhuman;  nuclear Overhauser effect;  plant leaf;  priority journal;  proton nuclear magnetic resonance;  Pseudomonas aeruginosa;  skin fibroblast;  Staphylococcus aureus;  Staphylococcus epidermidis;  thin layer chromatography;  analogs and derivatives;  bacterium;  chemical structure;  chemistry;  classification;  Cordia;  drug effects;  fibroblast;  fungus;  isolation and purification;  microbial sensitivity test;  plant root;  tumor cell line, Bacteria;  Cell Line, Tumor;  Cordia;  Fibroblasts;  Fungi;  Humans;  Indoles;  Mannosides;  Microbial Sensitivity Tests;  Molecular Structure;  Plant Bark;  Plant Extracts;  Plant Leaves;  Plant Roots;  Proanthocyanidins;  Quercetin",
    abstract = "Two new natural products, 5-O-[β-D-apiofuranosyl-(1 → 6)-β-D-glucopyranosyl]-1-isoindolinone (1) as well as N-(2E)-3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]acryloylglycine (2), along with four known compounds (3–6), were isolated from the methanolic extract of Cordia alliodora root bark. Furthermore, the methanolic extract of Cordia colloccoca leaves, afforded the known flavonoids afzelin (7) and quercitrin (8). The isolated secondary metabolites were assayed for their antimicrobial activities against a panel of 6 g positive and negative bacteria and three human pathogenic fungi. Moreover, their antiproliferative effect was also evaluated in vitro against the human non-small-cell bronchopulmonary carcinoma line NSCLC-N6, the epidermoid lung cancer cell line A549 as well as the normal human skin fibroblast cell line (AG01523). © 2016 Elsevier B.V."
}