@article{3022831,
    title = "Dobutamine administration exacerbates postischaemic myocardial dysfunction in isolated rat hearts: An effect reversed by thyroxine pretreatment",
    author = "Pantos, C. and Mourouzis, I. and Tzeis, S. and Moraitis, P. and Malliopoulou, V. and Cokkinos, D.D. and Carageorgiou, H. and Varonos, D. and Cokkinos, D.",
    journal = "European Journal of Pharmacology",
    year = "2003",
    volume = "460",
    number = "2-3",
    pages = "155-161",
    publisher = "Elsevier",
    issn = "0014-2999",
    doi = "10.1016/S0014-2999(02)02927-8",
    keywords = "dobutamine;  propranolol;  thyroxine, animal tissue;  article;  controlled study;  convalescence;  disease exacerbation;  drug effect;  heart function;  heart muscle ischemia;  heart muscle reperfusion;  long term care;  nonhuman;  priority journal;  rat",
    abstract = "The present study has investigated the effects of dobutamine on postischaemic dysfunction in the setting of global ischaemia and reperfusion in a model of isolated heart preparation. Isolated rat hearts were subjected to 20 min of zero-flow global ischaemia followed by 45 min of reperfusion. Dobutamine administration (10 μg/kg/min) during the reperfusion period resulted in deterioration of functional recovery, which was abolished by propranolol administration. Long-term thyroxine pretreatment (12.5 μg 100 g-1 body weight, b.i.d., s.c., for 2 weeks) reversed the detrimental effect of dobutamine and increased postischaemic recovery of function. We conclude that the combination of thyroxine pretreatment and dobutamine administration could potentially be a new therapeutic strategy to improve postischaemic dysfunction particularly in clinical settings such as cardiopulmonary bypass and/or myocardial infarction. © 2003 Elsevier Science B.V. All rights reserved."
}