@article{3022846,
    title = "Antifungal activity of secondary metabolites of Centaurea raphanina ssp. mixta, growing wild in Greece",
    author = "Panagouleas, C. and Skaltsa, H. and Lazari, D. and Skaltsounis, A.-L. and Sokovic, M.",
    journal = "PHARMACEUTICAL BIOLOGY",
    year = "2003",
    volume = "41",
    number = "4",
    pages = "266-270",
    publisher = "Swets en Zeitlinger B.V.",
    issn = "1388-0209",
    doi = "10.1076/phbi.41.4.266.15664",
    keywords = "Centaurea raphanina mixta extract;  cnicin;  miconazole;  polyphenol;  sesquiterpene lactone derivative;  unclassified drug, antifungal activity;  article;  Asteraceae;  bioassay;  Centauera raphanina mixta;  drug structure;  Greece;  in vitro study;  metabolite;  minimum inhibitory concentration;  plant;  Streptomyces, Asteraceae;  Centaurea;  Centaurea raphanina;  Centaurea raphanina;  Fungi;  Streptomyces",
    abstract = "The present study was carried out on the aerial parts of C. raphanina Sm. ssp. mixta (DC.) Runemark (Asteraceae), which is a commonly edible plant in Greece, on maturation stage. Although the isolation procedure is the appropriate one for the isolation of sesquiterpene lactones, the analysis revealed the presence of only one sesquiterpene lactone, namely cnicin, in small amounts. The main compounds were found to belong to polyphenols. The in vitro antifungal activity of the isolated compounds was tested, using the microdilution method. Only cnicin has been proved to be active against all fungi tested with a fungicidal potential higher than miconazole."
}