@article{3022986,
    title = "Studies on the physiological function of in vitro produced antioxidants from sage (Salvia officinalis L.): Effects on cell growth and metabolism",
    author = "Kintzios, S. and Adamopoulou, M. and Pistola, E. and Delki, K. and Drossopoulos, J.",
    journal = "Journal of Herbs, Spices and Medicinal Plants",
    year = "2002",
    volume = "9",
    number = "2-3",
    pages = "229-233",
    publisher = "Taylor and Francis Inc.",
    doi = "10.1300/J044v09n02_33",
    keywords = "antioxidant;  cytochrome c oxidase;  iron;  methanol;  oxidoreductase;  phenol derivative, antioxidant;  phenolic compound, antioxidant activity;  cell growth;  cell metabolism;  conference paper;  enzyme activity;  explant;  in vitro study;  mitochondrial respiration;  nonhuman;  plant physiology;  Salvia officinalis;  tissue culture, Salvia;  Salvia officinalis;  Salvia officinalis",
    abstract = "We investigated the effect of antioxidant phenolic compounds produced by sage (Salvia officinalis) callus cultures on some physiological parameters of the producing cells. Although cultures demonstrated a continuous growth during an incubation period of five weeks, the cell dehydrogenase activity, the cytochrome c oxidase activity and the respiration of isolated mitochondria declined. An analysis of methanolic extracts derived from the callus pieces indicated that the accumulation of phenolic compounds was correlated with mitochondrial activity, although the antioxidant activity (Fe+2 reduction) of the extracts was independent from any other physiological parameter. These results might elucidate some aspects of the physiological function of in vitro produced phenolic antioxidants from sage. © 2002 by The Haworth Press, Inc. All rights reserved."
}