@article{3023096,
    title = "Does stress influence ampicillin concentration in serum and tissues?",
    author = "Tesseromatis, C. and Trichilis, A. and Tsivos, E. and Messari, J. and Triantaphyllidis, H. and Varonos, D.D.",
    journal = "European Journal of Drug Metabolism and Pharmacokinetics",
    year = "2001",
    volume = "26",
    number = "3",
    pages = "167-171",
    publisher = "Editions Medecine et Hygiene",
    issn = "0378-7966, 2107-0180",
    doi = "10.1007/BF03190392",
    keywords = "albumin;  ampicillin;  fatty acid, adrenal gland;  animal experiment;  animal model;  animal tissue;  article;  binding affinity;  controlled study;  dose response;  drug binding;  drug blood level;  drug elimination;  drug tissue level;  exercise;  male;  nonhuman;  organ weight;  protein binding;  rat;  stress;  swimming",
    abstract = "Exercise produces changes of drug levels in plasma and increases the concentration of free fatty acids (FFAs), which may interfere with drug-protein binding. FFAs seem to play an antagonistic role to drugs since they have a strong binding capacity to serum albumin. The aim of this study was to evaluate the influence of the consecutive exercise-induced stress in ampicillin levels. Two groups of Wistar rats were used. Group A consisted of six subgroups that were subjected to cold swimming (4°C) for 5, 10, 15, 20, 25, 30 days respectively. Group B was the control group. The animals were injected im. with ampicillin (1 g/Kg/8h in 5 doses). Results showed that exercise enhanced stress parameters (FFAs, adrenal weight, Ht%) and led to an ampicillin increase in all experimental groups comparatively to controls."
}