@article{3023587,
    title = "Bioavailability of sulphamethoxazole-trimethoprim spheroidal granules",
    author = "Athanassiou, G.C. and Rekkas, D.M. and Choulis, N.H.",
    journal = "International Journal of Pharmaceutics",
    year = "1992",
    volume = "85",
    number = "1-3",
    pages = "209-212",
    issn = "0378-5173",
    doi = "10.1016/0378-5173(92)90151-Q",
    keywords = "cotrimoxazole;  sulfamethoxazole;  trimethoprim, adult;  area under the curve;  article;  drug bioavailability;  drug blood level;  drug formulation;  high performance liquid chromatography;  human;  human experiment;  male;  normal human;  priority journal",
    abstract = "The comparative bioavailability of a new formulation of sulfamethoxazole (SMZ) and trimethoprim (TMP), which was produced as reported previously (Athanassiou et al., Int. J. Pharm., 72 (1991) 141-147) and a reference product (Septrin, Wellcome), was assessed following administration to a group of healthy, male volunteers. Each volunteer received the test (T) and reference (R) formulation. Plasma concentrations of SMZ and TMP were monitored over a period of 12 h, after drug administration, using a new and sensitive HPLC method. All pharmacokinetic parameters showed wide intersubject variation. Maximum plasma concentration (Cmax), time to reach Cmax (Tmax) and the area under the curve up to the last measurement (AUClast0) and infinity (AUC0∞), were compared by analysis of variance or t-test and were found not to be significantly different among the two formulations. © 1992."
}