@article{3025457,
    title = "Synthesis of Novel Pyrazolo[3,4-b]pyridines with Affinity for β-Amyloid Plaques",
    author = "Vidali, V.P. and Nigianni, G. and Athanassopoulou, G.D. and Canko, A. and Mavroidi, B. and Matiadis, D. and Pelecanou, M. and Sagnou, M.",
    journal = "MolBank",
    year = "2022",
    volume = "2022",
    number = "1",
    publisher = "MDPI",
    doi = "10.3390/M1343",
    abstract = "Three novel pyrazolo[3,4-b]pyridines were synthesized via the cyclization of 5-amino-1-phenylpyrazole with the corresponding unsaturated ketone in the catalytic presence of ZrCl4. The ketones were afforded by modifying a stabilized ylide facilitated Wittig reaction in fairly high yields. The novel compounds exhibited exciting photophysical properties with the dimethylamine phenyl-bearing pyrazolopyridine showing exceptionally large Stoke’s shifts. Finally, both the dimethylamino-and the pyrene-substituted compounds demonstrated high and selective binding to amyloid plaques of Alzheimer’s disease (AD) patient brain slices upon fluorescent confocal microscopy observation. These results reveal the potential application of pyrazolo[3,4-b]pyridines in the development of AD amyloid plaque probes of various modalities for AD diagnosis. © 2022 by the authors. Licensee MDPI, Basel, Switzerland."
}