@article{3025725,
    title = "Fabrication and Characterization of Neurocompatible Ulvan-Based Layer-by-Layer Films",
    author = "Moon, H.C. and Choi, H. and Kikionis, S. and Seo, J. and Youn, W. and Ioannou, E. and Han, S.Y. and Cho, H. and Roussis, V. and Choi, I.S.",
    journal = "Langmuir",
    year = "2020",
    volume = "36",
    number = "39",
    pages = "11610-11617",
    publisher = "American Chemical Society",
    issn = "0743-7463, 1520-5827",
    doi = "10.1021/acs.langmuir.0c02173",
    keywords = "Adhesion;  Amino acids;  Neurons, Compositional similarities;  Extracellular matrices;  Fabrication and characterizations;  Glycosaminoglycans;  Layer-by-layer films;  Neurite outgrowth;  Primary hippocampal neurons;  Sulfated polysaccharides, Fabrication",
    abstract = "Construction of extracellular matrix-mimetic nanofilms has considerable potential in biomedical and nanomedicinal fields. In this work, we fabricated neurocompatible layer-by-layer (LbL) films based on ulvan (ULV), a highly sulfated polysaccharide having compositional similarity to glycosaminoglycans that play important functional roles in the brain. ULV was durably assembled as a film with chitosan, another marine-derived polysaccharide, and the film enabled the stable adhesion of primary hippocampal neurons with high viability, comparable to the conventional poly-d-lysine surface. Notably, the ULV-based LbL films accelerated neurite outgrowth and selectively suppressed the adhesion of astrocytes, highlighting its potential as an advanced platform for neural implants and devices. © 2020 American Chemical Society."
}