@article{3025961,
    title = "Synthesis, characterization and antimicrobial activity of N-acetyl-3-acetyl-5-benzylidene tetramic acid-metal complexes. X-ray analysis and identification of the Cd(II) complex as a potent antifungal agent",
    author = "Matiadis, D. and Tsironis, D. and Stefanou, V. and Elliott, A.G. and Kordatos, K. and Zahariou, G. and Ioannidis, N. and McKee, V. and Panagiotopoulou, A. and Igglessi-Markopoulou, O. and Markopoulos, J.",
    journal = "Journal of Inorganic Biochemistry",
    year = "2019",
    volume = "194",
    pages = "65-73",
    publisher = "ELSEVIER SCIENCE INC 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA",
    issn = "0162-0134",
    doi = "10.1016/j.jinorgbio.2019.02.008",
    keywords = "acetic acid derivative;  antifungal agent;  cadmium;  cobalt;  copper;  manganese;  metal complex;  nickel;  tetramic acid derivative;  zinc;  antifungal agent;  antiinfective agent;  coordination compound, Acinetobacter baumannii;  antifungal activity;  Article;  Candida albicans;  carbon nuclear magnetic resonance;  Cryptococcus neoformans;  drug structure;  drug synthesis;  electron spin resonance;  embryo;  Escherichia coli;  hemolysis;  human;  human cell;  Klebsiella pneumoniae;  methicillin resistant Staphylococcus aureus;  minimum inhibitory concentration;  nonhuman;  proton nuclear magnetic resonance;  Pseudomonas aeruginosa;  thermostability;  X ray analysis;  bacterium;  chemistry;  Deuteromycetes;  drug effect;  erythrocyte;  HEK293 cell line;  microbial sensitivity test;  synthesis;  X ray crystallography, Anti-Bacterial Agents;  Antifungal Agents;  Bacteria;  Cadmium;  Coordination Complexes;  Crystallography, X-Ray;  Erythrocytes;  HEK293 Cells;  Hemolysis;  Humans;  Microbial Sensitivity Tests;  Mitosporic Fungi",
    abstract = "This study aims at the further expansion of knowledge on the antimicrobial activities of the tetramic acid moiety and the effect of metal complexation. Complexes of the N-acetyl-3-acetyl-5-benzylidenetetramic acid with Mn, Co, Ni, Cu, Zn and Cd were synthesized and screened against 5 key ESKAPE pathogens (Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa) and 2 fungi (Cryptococcus neoformans and Candida albicans). The cadmium complex was found to effectively inhibit the fungus Cryptococcus neoformans with minimum inhibitory concentration (MIC) of 8 μg/mL, with no human cell toxicity and hemolytic activity within the tested concentration range. The biologically active tetramic acid‑cadmium complex was structurally characterized by single-crystal X-ray analysis. Furthermore, the thermal stability of the ligand and the complexes was investigated along with NMR and EPR studies of the Cd(II) and Co(II) complexes respectively. © 2019 Elsevier Inc."
}