@article{3026042,
    title = "Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer",
    author = "Klein, A.P. and Wolpin, B.M. and Risch, H.A. and Stolzenberg-Solomon, R.Z. and Mocci, E. and Zhang, M. and Canzian, F. and Childs, E.J. and Hoskins, J.W. and Jermusyk, A. and Zhong, J. and Chen, F. and Albanes, D. and Andreotti, G. and Arslan, A.A. and Babic, A. and Bamlet, W.R. and Beane-Freeman, L. and Berndt, S.I. and Blackford, A. and Borges, M. and Borgida, A. and Bracci, P.M. and Brais, L. and Brennan, P. and Brenner, H. and Bueno-De-Mesquita, B. and Buring, J. and Campa, D. and Capurso, G. and Cavestro, G.M. and Chaffee, K.G. and Chung, C.C. and Cleary, S. and Cotterchio, M. and Dijk, F. and Duell, E.J. and Foretova, L. and Fuchs, C. and Funel, N. and Gallinger, S. and Gaziano, J.M.M. and Gazouli, M. and Giles, G.G. and Giovannucci, E. and Goggins, M. and Goodman, G.E. and Goodman, P.J. and Hackert, T. and Haiman, C. and Hartge, P. and Hasan, M. and Hegyi, P. and Helzlsouer, K.J. and Herman, J. and Holcatova, I. and Holly, E.A. and Hoover, R. and Hung, R.J. and Jacobs, E.J. and Jamroziak, K. and Janout, V. and Kaaks, R. and Khaw, K.-T. and Klein, E.A. and Kogevinas, M. and Kooperberg, C. and Kulke, M.H. and Kupcinskas, J. and Kurtz, R.J. and Laheru, D. and Landi, S. and Lawlor, R.T. and Lee, I.-M. and Lemarchand, L. and Lu, L. and Malats, N. and Mambrini, A. and Mannisto, S. and Milne, R.L. and Mohelníková-Duchoňová, B. and Neale, R.E. and Neoptolemos, J.P. and Oberg, A.L. and Olson, S.H. and Orlow, I. and Pasquali, C. and Patel, A.V. and Peters, U. and Pezzilli, R. and Porta, M. and Real, F.X. and Rothman, N. and Scelo, G. and Sesso, H.D. and Severi, G. and Shu, X.-O. and Silverman, D. and Smith, J.P. and Soucek, P. and Sund, M. and Talar-Wojnarowska, R. and Tavano, F. and Thornquist, M.D. and Tobias, G.S. and Van Den Eeden, S.K. and Vashist, Y. and Visvanathan, K. and Vodicka, P. and Wactawski-Wende, J. and Wang, Z. and Wentzensen, N. and White, E. and Yu, H. and Yu, K. and Zeleniuch-Jacquotte, A. and Zheng, W. and Kraft, P. and Li, D. and Chanock, S. and Obazee, O. and Petersen, G.M. and Amundadottir, L.T.",
    journal = "Nature Communications",
    year = "2018",
    volume = "9",
    number = "1",
    publisher = "Nature Publishing Group",
    issn = "2041-1723",
    doi = "10.1038/s41467-018-02942-5",
    keywords = "ancestry;  cancer;  genome;  identification method;  meta-analysis, allele;  Article;  cancer genetics;  cancer patient;  case control study;  cohort analysis;  controlled study;  expression quantitative trait locus;  gene replication;  genetic susceptibility;  genome-wide association study;  human;  major clinical study;  meta analysis (topic);  pancreas cancer;  genetic database;  genetic predisposition;  genetics;  meta analysis;  pancreas carcinoma;  pancreas tumor;  single nucleotide polymorphism, Europe;  United States, hepatocyte nuclear factor 1beta;  hepatocyte nuclear factor 4;  HNF1B protein, human;  HNF4G protein, human;  NOC2L protein, human;  protein;  repressor protein;  tensin;  TNS3 protein, human;  Ucma protein, human, Carcinoma, Pancreatic Ductal;  Databases, Genetic;  Genetic Predisposition to Disease;  Genome-Wide Association Study;  Hepatocyte Nuclear Factor 1-beta;  Hepatocyte Nuclear Factor 4;  Humans;  Pancreatic Neoplasms;  Polymorphism, Single Nucleotide;  Proteins;  Repressor Proteins;  Tensins",
    abstract = "In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: Rs13303010 at 1p36.33 (NOC2L, P = 8.36 × 10-14), rs2941471 at 8q21.11 (HNF4G, P = 6.60 × 10-10), rs4795218 at 17q12 (HNF1B, P = 1.32 × 10-8), and rs1517037 at 18q21.32 (GRP, P = 3.28 × 10-8). rs78417682 is not statistically significantly associated with pancreatic cancer in PANDoRA. Expression quantitative trait locus analysis in three independent pancreatic data sets provides molecular support of NOC2L as a pancreatic cancer susceptibility gene. © 2018 The Author(s)."
}