@article{3026284,
    title = "The use of J-coupling as a sole criterion to assign the total absolute stereochemistry of new pyrrolidinone class synthetic analogs, derived from S-pyroglutamic acid",
    author = "Kellici, T.F. and Ntountaniotis, D. and Vanioti, M. and Golic Grdadolnik, S. and Simcic, M. and Michas, G. and Moutevelis-Minakakis, P. and Mavromoustakos, T.",
    journal = "Journal of Molecular Structure",
    year = "2017",
    volume = "1129",
    pages = "195-199",
    publisher = "Elsevier B.V.",
    issn = "0022-2860",
    doi = "10.1016/j.molstruc.2016.09.075",
    keywords = "Bioactivity;  Nuclear magnetic resonance spectroscopy;  Organic compounds;  Stereochemistry, Absolute stereochemistry;  Chiral centers;  J coupling;  Pyroglutamic acids;  Pyrrolidinone;  Synthetic analogs, Stereoselectivity",
    abstract = "During the synthesis of new pyrrolidinone analogs possessing biological activity it is intriguing to assign their absolute stereochemistry as it is well known that drug potency is influenced by the stereochemistry. The combination of J-coupling information with theoretical results was used in order to establish their total stereochemistry when the chiral center of the starting material has known absolute stereochemistry. The J-coupling can be used as a sole criterion for novel synthetic analogs to identify the right stereochemistry. This approach is extremely useful especially in the case of analogs whose 2D NOESY spectra cannot provide this information. Few synthetic examples are given to prove the significance of this approach. © 2016 Elsevier B.V."
}