@article{3029820,
    title = "Novel Insights for Patients with Multiple Basal Cell Carcinomas and
Tumors at High-Risk for Recurrence: Risk Factors, Clinical Morphology,
and Dermatoscopy",
    author = "Sgouros, Dimitrios and Rigopoulos, Dimitrios and Panayiotides, Ioannis and and Apalla, Zoe and Arvanitis, Dimitrios K. and Theofili, Melpomeni and and Theotokoglou, Sofia and Syrmali, Anna and Theodoropoulos, Konstantinos and and Pappa, Georgia and Damaskou, Vasileia and Stratigos, Alexander and and Katoulis, Alexander",
    journal = "Blood cancer journal",
    year = "2021",
    volume = "13",
    number = "13",
    publisher = "MDPI",
    doi = "10.3390/cancers13133208",
    keywords = "basal cell carcinoma; dermatoscopy; histopathology; skin cancer;
diagnosis; non-melanoma skin cancer; prevention",
    abstract = "Simple Summary We investigated 225 patients with 304 primary basal cell
carcinomas (BCCs) and we conducted a retrospective, morphological,
cohort study aimed at evaluating patients’ demographics and tumors’
clinical and dermatoscopic characteristics. Our main objectives were the
detection of risk factors for multiple BCCs in individual patients and
the description of clinical and dermatoscopic features of low and high
risk for local recurrence tumors. The rising incidence of BCC and the
occurrence of multiple tumors in individual patients poses BCC as a
major issue for health systems. To the best of our knowledge, this is
one of the first studies to attempt to unveil clinical and dermatoscopic
features of low-/high-risk neoplasms beyond histopathology and take into
equal account parameters, such as anatomic location and size of the
lesion. We strongly support that profiling of multiple patients with
BCCs and a thorough knowledge of high-risk tumors’ clinico-dermatoscopic
morphology could provide physicians with important information towards
prevention of this neoplasm. Introduction: Basal cell carcinoma (BCC)
quite frequently presents as multiple tumors in individual patients.
Neoplasm’s risk factors for local recurrence have a critical impact on
therapeutic management. Objective: To detect risk factors for multiple
BCCs (mBCC) in individual patients and to describe clinical and
dermatoscopic features of low- and high-risk tumors. Materials &
Methods: Our study included 225 patients with 304 surgically excised
primary BCCs. All patients’ medical history and demographics were
recorded. Clinical and dermatoscopic images of BCCs were evaluated for
predefined criteria and statistical analyses were performed. Results:
Grade II-III sunburns before adulthood (OR 2.146, p = 0.031) and a
personal history of BCC (OR 3.403, p < 0.001) were the major
predisposing factors for mBCC. Clinically obvious white color (OR 3.168,
p < 0.001) and dermatoscopic detection of white shiny lines (OR 2.085, p
= 0.025) represented strongly prognostic variables of high-risk BCC.
Similarly, extensive clinico-dermatoscopic ulceration (up to 9.2-fold)
and nodular morphology (3.6-fold) raise the possibility for high-risk
BCC. On the contrary, dermatoscopic evidence of blue-black coloration
had a negative prognostic value for high-risk neoplasms (light OR 0.269,
p < 0.001/partial OR 0.198, p = 0.001). Conclusions: Profiling of mBCC
patients and a thorough knowledge of high-risk tumors’
clinico-dermatoscopic morphology could provide physicians with important
information towards prevention of this neoplasm."
}