@article{3030098,
    title = "Impact of a 4-year antimicrobial stewardship program implemented in a
Greek tertiary hospital",
    author = "Chrysou, Konstantina and Zarkotou, Olympia and Kalofolia, Sofia and and Papagiannakopoulou, Panagiota and Mamali, Vasiliki and Chrysos, Georgios and and Themeli-Digalaki, Katina and Sypsas, Nikolaos and Tsakris, and Athanasios and Pournaras, Spyros",
    journal = "European Journal of Clinical Microbiology & Infectious Diseases",
    year = "2022",
    volume = "41",
    number = "1",
    pages = "127-132",
    publisher = "Springer-Verlag",
    issn = "0934-9723, 1435-4373",
    doi = "10.1007/s10096-021-04290-7",
    keywords = "Antibiotic consumption; Antimicrobial stewardship; Clostridioides
difficile infections; Antibiotic costs; Length of hospital stay",
    abstract = "This study aimed to investigate the effects of a 4-year antibiotic
stewardship program (ASP) in a tertiary hospital. We monitored data for
2015 (pre-intervention) and 2016-2019 (post-intervention) about
antibiotic consumption (DDD/100 bed days), Clostridioides difficile
infections (CDIs), resistance rates, length of stay (LOS), and annual
antibiotic costs. Significant reductions were observed for total
antibiotics/colistin/ carbapenems/quinolones/tigecycline consumption and
resistance rates of Pseudomonas aeruginosa, Klebsiella pneumoniae, and
vancomycin-resistant enterococci. Considerable reductions occurred for
LOS (4.18 [2015]/3.0 [2019] days), CDIs (1.47 [2015]/0.86 [2019]
per 1000 patients), antibiotic cost/patient (39.45(sic)
[2015]/23.69(sic) [2019]). The ASP was successful in reducing
antibiotic consumption, antibiotic costs, length of hospital stay, and
CDIs."
}