@article{3030201,
    title = "The effects of aging on molecular modulators of human embryo
implantation",
    author = "Ntostis, Panagiotis and Swanson, Grace and Kokkali, Georgia and Iles, and David and Huntriss, John and Pantou, Agni and Tzetis, Maria and Pantos, and Konstantinos and Picton, Helen M. and Krawetz, Stephen A. and Miller, and David",
    journal = "ISCIENCE",
    year = "2021",
    volume = "24",
    number = "7",
    publisher = "Cell Press",
    doi = "10.1016/j.isci.2021.102751",
    abstract = "Advancing age has a negative impact on female fertility. As implantation
rates decline during the normal maternal life course, age-related,
embryonic factors are altered and our inability to monitor these factors
in an unbiased genome-wide manner in vivo has severely limited our
understanding of early human embryo development and implantation. Our
high-throughput methodology uses trophectoderm samples representing the
full spectrum of maternal reproductive ages with embryo implantation
potential examined in relation to trophectoderm transcriptome dynamics
and reproductive maternal age. Potential embryo-endometrial interactions
were tested using trophectoderm sampled from young women, with the
receptive uterine environment representing the most `fertile'
environment for successful embryo implantation. Potential roles for
extracellular exosomes, embryonic metabolism and regulation of apoptosis
were revealed. These biomarkers are consistent with embryo-endometrial
crosstalk/developmental competency, serving as a mediator for successful
implantation. Our data opens the door to developing a diagnostic test
for predicting implantation success in women undergoing fertility
treatment."
}