@article{3030333,
    title = "Lack of Association Between the ACE2 G8790A Gene Variation and Risk for
Basal Cell Carcinoma",
    author = "Gintoni, Iphigenia and Vassiliou, Stavros and Avgoustidis, Dimitris and and Adamopoulou, Mary and Zavras, Nikolaos and Papakosta, Veronica and and Vlachakis, Dimitris and Yapijakis, Christos",
    journal = "ANTICANCER RESEARCH",
    year = "2021",
    volume = "41",
    number = "8",
    pages = "4021-4026",
    publisher = "INT INST ANTICANCER RESEARCH",
    issn = "0250-1291",
    doi = "10.21873/anticanres.15201",
    keywords = "Basal cell carcinoma; angiotensin-converting enzyme 2; angiotensin;
G8790A; rs2285666; DNA polymorphism; skin cancer",
    abstract = "Background/Aim: The G8790A (rs2285666) functional polymorphism of the
angiotensin-converting enzyme 2 (ACE2) gene influences alternative mRNA
splicing and quantitatively affects the enzyme's production.
Specifically, the presence of the A allele has been associated with
higher ACE2 plasma levels. In this study, we investigated the possible
association of the functional polymorphism ACE2-G8790A with the
pathogenesis of basal cell carcinoma (BCC). Patients and Methods: A
total of 190 DNA samples were studied, including 91 BCC patients and 99
controls of Greek origin. Molecular genotyping for the ACE2 G8790A
polymorphism was carried out by PCR amplification, followed by AluI
enzyme digestion and agarose gel electrophoresis of the DNA fragments.
Results: The allelic and genotypic frequencies presented no statistical
difference between the patient and the control group. Conclusion: There
is no association between the ACE2 G8790A polymorphism and pathogenesis
of BCC."
}