@article{3030335,
    title = "Impact of PD-L1 Protein Expression on Renal Cell Carcinoma
Histo-differentiation",
    author = "Tziakou, Paraskevi and Theodoropoulos, Grigorios and Tsiambas, Evangelos and and Zizi-sermpetzoglou, Adamantia and Peschos, Dimitrios and and Mastronikoli, Sofianiki and Thomopoulou, Georgia and Thymara, Eirini and and Kavantzas, Nikolaos and Lazaris, Andreas C.",
    journal = "ANTICANCER RESEARCH",
    year = "2021",
    volume = "41",
    number = "8",
    pages = "3809-3813",
    publisher = "INT INST ANTICANCER RESEARCH",
    issn = "0250-1291",
    doi = "10.21873/anticanres.15173",
    keywords = "Renal; carcinoma; PD-L1; protein; immunotherapy; differentiation",
    abstract = "Background/Aim: Renal cell carcinoma (RCC) comprises a variety of
pathological entities. Many RCCs are aggressive, demanding efficient
targeted and immune-therapeutic strategies. Programmed cell death
ligand-1 (PD-L1) is expressed mainly in hematopoietic cells and also in
epithelial cells. The aim of this study was to correlate PD-L1 protein
expression in a series of RCC tissues with their histo-pathological
features. Materials and Methods: One hundred (n=100) archival,
formalin-fixed and paraffin-embedded RCC tissue specimens were analysed
by immunohistochemistry. Conventional tumor proportion score (TPS)
qualitative assay was applied for evaluating protein expression levels.
Results: Based on the TPS evaluation, 8 (8%) cases were characterized
as positive, and the rest of them (n=92; 92%) as negative. A
progressive increase in PD-L1 positivity was significantly associated
with the differentiation grade of the examined malignancies (p=0.001).
Conclusion: Although PD-L1 over-expression is detected in low rates in
RCCs, its correlation with differentiation grade should be considered as
a factor for discriminating sub-groups of patients with specific
histo-pathological features eligible for targeted anti-PD-L1
immunotherapy strategies."
}