@article{3030590,
    title = "Arterial biomarkers in the evaluation, management and prognosis of
aortic stenosis",
    author = "Gardikioti, Vasiliki and Terentes-Printzios, Dimitrios and Iliopoulos, and Dimitrios and Aznaouridis, Konstantinos and Sigala, Evangelia and and Tsioufis, Konstantinos and Vlachopoulos, Charalambos",
    journal = "Atherosclerosis",
    year = "2021",
    volume = "332",
    pages = "1-15",
    publisher = "Elsevier Ireland Ltd",
    issn = "0021-9150",
    doi = "10.1016/j.atherosclerosis.2021.07.006",
    keywords = "Aortic valve stenosis; Arterial stiffness; Arterial biomarkers; Pulse
wave velocity; Arterial compliance",
    abstract = "Degenerative aortic valve stenosis is the most common primary valve
disease and a significant cause of cardiovascular morbidity and
mortality. In an era when new techniques for the management of aortic
stenosis are gaining ground, the understanding of this disease is more
important than ever to optimize treatment. So far, the focus has been
placed on the assessment of the valve itself. However, the role that the
arterial system plays in the pathogenesis and natural history of the
disease needs to be further elucidated. Arteriosclerosis, when it
coexists with a stenotic valve, augments the load posed on the left
ventricle contributing to greater impairment of cardiovascular function.
Arterial stiffness, a well-established predictor for cardiovascular
disease and all-cause mortality, could play a role in the prognosis and
quality of life of this population. Several studies using a variety of
indices to assess arterial stiffness have tried to address the potential
utility of arterial function assessment in the case of aortic stenosis.
Importantly, reliable data identify a prognostic role of arterial
biomarkers in aortic stenosis and stress their possible use to optimize
timing and method of treatment. This review aims at summarizing the
existing knowledge on the interplay between the heart and the vessels in
the presence of degenerative aortic stenosis, prior, upon and after
interventional management. Further, it discusses the evidence supporting
the potential clinical application of arterial biomarkers for the
assessment of progression, severity, management and prognosis of aortic
stenosis."
}