@article{3031043,
    title = "Phenotypic/Genotypic Profile of OXA-10-Like-Harboring,
Carbapenem-Resistant Pseudomonas aeruginosa: Using Validated
Pharmacokinetic/Pharmacodynamic In Vivo Models To Further Evaluate
Enzyme Functionality and Clinical Implications",
    author = "Gill, Christian M. and Brink, Adrian and Chu, Chun Yat and Coetzee, and Jennifer and Dimopoulos, George and Moodley, Clinton and Opperman, and Christoffel Johannes and Pournaras, Spyros and Tenover, Fred C. and and Tickler, Isabella A. and Tootla, Hafsah Deepa and Vourli, Sophia and and Nicolau, David P.",
    journal = "Antimicrobial Agents and Chemotherapy",
    year = "2021",
    volume = "65",
    number = "10",
    publisher = "AMER SOC MICROBIOLOGY",
    issn = "0066-4804, 1098-6596",
    doi = "10.1128/AAC.01274-21",
    keywords = "Pseudomonas aeruginosa; carbapenem resistant; cefepime; ceftazidime; in
vivo; pharmacodynamics; pharmacokinetics",
    abstract = "In vitro MICs and in vivo pharmacodynamics of ceftazidime and cefepime
human-simulated regimens (HSR) against modified carbapenem inactivation
method (mCIM)-positive Pseudomonas aeruginosa isolates harboring
different OXA-10-like sub-types were described. The murine thigh model
assessed ceftazidime (2 g every 8 h [q8h] HSR) and cefepime (2 g and 1
g q8h HSR). Phenotypes were similar despite possessing OXA-10-like
subtypes with differing spectra. Ceftazidime produced >= 1-log(10)
killing in all isolates. Cefepime activity was dose dependent and MIC
driven. This approach may be useful in assessing the implications of
beta-lactamase variants."
}