@article{3031790,
    title = "Updates and Ongoing Challenges in Imaging of Multiple Myeloma: AJR
Expert Panel Narrative Review",
    author = "Wu, Fangbai and Bernard, Stephanie and Fayad, Laura M. and Ilaslan, and Hakan and Messiou, Christina and Moulopoulos, Lia Angela and Mulligan, and Michael E.",
    journal = "AJR.  AMERICAN JOURNAL OF ROENTGENOLOGY",
    year = "2021",
    volume = "217",
    number = "4",
    pages = "775-785",
    publisher = "AMER ROENTGEN RAY SOC",
    issn = "0361-803X",
    doi = "10.2214/AJR.21.25878",
    keywords = "International Myeloma Working Group; multiple myeloma; PET/CT;
whole-body low-dose CT; whole-body MRI",
    abstract = "Advances in the understanding and treatment of multiple myeloma have led
to the need for more sensitive and accurate imaging of intramedullary
and extramedullary disease. This role of imaging is underscored by
recently revised imaging recommendations of the International Myeloma
Working Group (IMWG). This narrative review discusses these
recommendations from the IMWG for different disease stages, focusing on
advanced whole-body modalities, and addresses related challenges and
controversies. In the recommendations, whole-body low-dose CT is central
in initial patient assessment, replacing the conventional skeletal
survey. Although the recommendations favor MRI for diagnosis because of
its superior sensitivity and utility in identifying myeloma-defining
events, FDG PET/CT is recommended as the modality of choice for
assessing treatment response. Consensus opinions are offered regarding
the role of imaging in multiple myeloma for characterization of disease
distribution, determination of prognosis, and response evaluation."
}