@article{3032750,
    title = "Diagnostic Performance of Frequency-Domain Optical Coherence Tomography
to Predict Functionally Significant Left Main Coronary Artery Stenosis",
    author = "Bouki, Konstantina P. and Vlad, I, Delia and Goulas, Nikolaos and and Lambadiari, Vaia A. and Dimitriadis, George D. and Kotsakis, Athanasios and A. and Baroutsi, Kyriaki and Toutouzas, Konstantinos P.",
    journal = "Journal of Interventional Cardiology",
    year = "2021",
    volume = "2021",
    publisher = "WILEY-HINDAWI",
    issn = "0896-4327, 1540-8183",
    doi = "10.1155/2021/7108284",
    abstract = "Aims. The aim of this study was to assess the safety and diagnostic
efficacy of frequency-domain optical coherence tomography (FD-OCT) in
identifying functional severity of the left main coronary artery (LM)
stenosis determined by fractional flow reserve (FFR). Methods and
Results. 101 patients with LM lesion (20-70% diameter stenosis
angiographically) underwent FFR measurement and FD-OCT imaging of the
LM. The following parameters were measured by FD-OCT in the LM:
reference lumen area (RLA), reference lumen diameter (RLD), minimum
lumen area (MLA), minimum lumen diameter (MLD), % lumen area stenosis,
and % diameter stenosis. The LM lesions were analyzable by FD-OCT in
88/101 (87.1%) patients. FFR at maximum hyperemia was <= 0.80 in 39/88
(44.3%) patients. FFR values were correlated significantly with
FD-OCT-derived LM lumen parameters. An MLA cutoff value of 5.38 mm(2)
had the highest sensitivity and specificity of 82% and 81%,
respectively, followed by an MLD of 2.43 mm (sensitivity 77%,
specificity 72%) and AS of 60% (sensitivity 72%, specificity 72%)
for predicting FFR Conclusions. FD-OCT is a safe and feasible imaging
technique for the assessment of LM stenosis. An FD-OCT-derived MLA of <=
5.38 mm(2) strongly predicts the functional severity of an LM lesion."
}