@article{3032769,
    title = "Male Age and Progressive Sperm Motility Are Critical Factors Affecting
Embryological and Clinical Outcomes in Oocyte Donor ICSI Cycles",
    author = "Vogiatzi, Paraskevi and Pouliakis, Abraham and Sakellariou, Maria and and Athanasiou, Aikaterini and Athanasiou, Adamantios and Colaghis, and Alexandros and Finelli, Renata and Loutradis, Dimitrios and Henkel, Ralf and and Agarwal, Ashok",
    journal = "Animal Reproduction Science",
    year = "2022",
    volume = "29",
    number = "3",
    pages = "883-895",
    publisher = "Springer Berlin Heidelberg",
    issn = "0378-4320",
    doi = "10.1007/s43032-021-00801-1",
    keywords = "Male infertility; Paternal age; Semen analysis; Oocyte donation; IVF;
ICSI",
    abstract = "This retrospective cohort study aimed to explore whether paternal age
and semen quality parameters affect the embryological and clinical
outcomes of ICSI with oocyte donation. A total of 339 oocyte donation
(OD)-ICSI cycles were categorized into four groups according to the
semen parameter profiles of the male counterparts: normozoospermia (NS,
n = 184), oligozoospermia (OS, n = 41), asthenozoospermia (AS, n = 50),
and oligoasthenozoospermia (OAS, n = 64). The effect of age, total sperm
count, and progressive motility was separately analyzed for reproductive
outcomes and compared between the study groups: fertilization,
blastulation, and top-quality embryo rate, biochemical and clinical
pregnancy, live birth, and miscarriage. A negative correlation between
male age and fertilization rate was observed (r(s) = - 0.23, p <
0.0001), while male age was a significant factor for biochemical
pregnancy (p = 0.0002), clinical pregnancy (p = 0.0017), and live birth
(p = 0.0038). Reduced total sperm count and lowered progressive motility
led to poorer fertilization rates (r(s) = 0.19 and 0.35, respectively, p
< 0.0001) and affected embryo quality (r(s) = 0.13, p = 0.02, and r(s) =
0.22, p < 0.0001, respectively). OD-ICSI cycles with asthenozoospermia
had significantly lowered success rates in biochemical pregnancy,
clinical pregnancy, and live birth (p < 0.05). Our study demonstrated
that both advanced male age and reduced progressive motility of
spermatozoa exert a significant negative influence on the outcome of
assisted reproduction, even in controlled procedures with gamete
selection and optimization such as in OD-ICSI. Improvement in treatment
strategies and male fertility evaluation requires incorporation of such
evidence to obtain better prognosis towards personalized management."
}