@article{3033081,
    title = "Macular Hemorrhage Due to Age-Related Macular Degeneration or Retinal
Arterial Macroaneurysm: Predictive Factors of Surgical Outcome",
    author = "Pierre, Mitta and Mainguy, Adam and Chatziralli, Irini and Pakzad-Vaezi, and Kaivon and Ruiz-Medrano, Jorge and Bodaghi, Bahram and Loewenstein, Anat and and Ambati, Jayakrishna and de Smet, Marc D. and Tadayoni, Ramin and and Touhami, Sara",
    journal = "Journal of Clinical Medicine Research",
    year = "2021",
    volume = "10",
    number = "24",
    publisher = "MDPI",
    issn = "1918-3003, 1918-3011",
    doi = "10.3390/jcm10245787",
    keywords = "age-related macular degeneration; macular hemorrhage; macular hematoma;
treat and extend; prognosis; retinal arterial macroaneurysm; vitrectomy",
    abstract = "Objective: The study aimed to determine the outcomes and prognostic
factors of vitrectomy, subretinal injection of tissue-plasminogen
activator and gas tamponade in macular hemorrhage (MaH) due to
age-related macular degeneration (AMD) or retinal arterial macroaneurysm
(RAM). Methods: The study design utilized a multicentric retrospective
case series design of consecutive patients undergoing surgery between
2014 and 2019. Results: A total of 65 eyes from 65 patients were
included in the study. Surgery was performed after a mean period of 7.1
days. Displacement of MaH was achieved in 82% of the eyes. Mean
best-corrected visual acuity (BCVA) improved from 20/500 to 20/125 at
month(M)1 and M6 (p < 0.05). At M6, BCVA worsening was associated with
an older age at diagnosis (p = 0.0002) and higher subretinal OCT
elevation of MaH (p = 0.03). The use of treat and extend (TE) (OR =
16.7, p = 0.001) and small MaH fundus size (OR = 0.64 and 0.74 for
horizontal and vertical fundus size, p < 0.05) were predictive of a
higher likelihood of obtaining a countable BCVA at M1. Baseline BCVA was
predictive of postoperative BCVA (p < 0.05). Retinal detachment and MaH
recurrence occurred in 3% and 9.3% of cases at M6. Conclusion: MaH
surgery stabilizes or improves BCVA in 85% of cases. Younger age at
diagnosis, better baseline BCVA figures, smaller subretinal MaH height
and use of TE regime were predictive of the best postoperative outcomes."
}