@article{3033214,
    title = "Genetic Polymorphisms Involved in Mitochondrial Metabolism and
Pancreatic Cancer Risk",
    author = "Peduzzi, Giulia and Gentiluomo, Manuel and Tavano, Francesca and and Arcidiacono, Paolo Giorgio and Ermini, Stefano and Vodicka, Pavel and and Boggi, Ugo and Cavestro, Giulia Martina and Capurso, Gabriele and and Morelli, Luca and Milanetto, Anna Caterina and Pezzilli, Raffaele and and Lawlor, Rita T. and Carrara, Silvia and Lovecek, Martin and Souc, Pavel and and Guo, Feng and Hackert, Thilo and Uzunoglu, Faik G. and Gazouli, and Maria and Parniczky, Andrea and Kupcinskas, Juozas and Bijlsma, Maarten and F. and Bueno-de-Mesquita, Bas and Vermeulen, Roel and van Eijck, Casper and H. J. and Jamroziak, Krzysztof and Talar-Wojnarowska, Renata and and Greenhalf, William and Gioffreda, Domenica and Petrone, Maria C. and and Landi, Stefano and Archibugi, Livia and Puzzono, Marta and Funel, and Niccola and Sperti, Cosimo and Piredda, Maria L. and and Mohelnikova-Duchonova, Beatrice and Lu, Ye and Hlavac, Viktor and Gao, and Xin and Schneider, Martin and Izbicki, Jakob R. and Theodoropoulos, and George and Bunduc, Stefania and Kreivenaite, Edita and Busch, Olivier R. and and Malecka-Panas, Ewa and Costello, Eithne and Perri, Francesco and and Testoni, Sabrina Gloria Giulia and Vanella, Giuseppe and Pasquali, and Claudio and Oliverius, Martin and Brenner, Hermann and Loos, Martin and and Gotz, Mara and Georgiou, Konstantinos and Eross, Alint and Maiello, and Evaristo and Szentesi, Andrea and Bazzocchi, Francesca and Basso, and Daniela and Neoptolemos, John P. and Hegyi, P. Eter and Kiudelis, and Vytautas and Canzian, Federico and Campa, Daniele",
    journal = "Cancer Epidemiology, Biomarkers & Prevention",
    year = "2021",
    volume = "30",
    number = "12",
    pages = "2342-2345",
    publisher = "AMER ASSOC CANCER RESEARCH",
    issn = "1055-9965, 1538-7755",
    doi = "10.1158/1055-9965.EPI-21-0353",
    abstract = "Background: The mitochondrial metabolism has been associated with
pancreatic ductal adenocarcinoma (PDAC) risk. Recent evidence also
suggests the involvement of the genetic variability of the mitochondrial
function in several traits involved in PDAC etiology. However, a
systematic investigation of the genetic variability of mitochondrial
genome (mtSNP) and of all the nuclear genes involved in its functioning
(n-mtSNPs) has never been reported.
Methods: We conducted a two-phase association study of mtSNPs and
n-mtSNPs to assess their effect on PDAC risk. We analyzed 35,297
n-mtSNPs and 101 mtSNPs in up to 55,870 individuals (12,884 PDAC cases
and 42,986 controls). In addition, we also conducted a gene-based
analysis on 1,588 genes involved in mitochondrial metabolism using
Multi-marker Analysis of GenoMic Annotation (MAGMA) software.
Results: In the discovery phase, we identified 49 n-mtSNPs and no mtSNPs
associated with PDAC risk (P < 0.05). In the second phase, none of the
findings were replicated. In the gene-level analysis, we observed that
three genes (TERT, SUGCT, and SURF1) involved in the mitochondrial
metabolism showed an association below the Bonferroni-corrected
threshold of statistical significance (P = 0.05/1588 - 3.1 x 10(-5)).
Conclusions: Even though the mitochondrial metabolism might be involved
in PDAC etiology, our results, obtained in a study with one of the
largest sample sizes to date, show that neither n-mtSNPs nor mtSNPs are
associated with PDAC risk."
}