@article{3033710,
    title = "<p>Association of TNF-a 308G/A and LEPR Gln223Arg Polymorphisms with the
Risk of Type 2 Diabetes Mellitus</p>",
    author = "Trapali, Maria and Houhoula, Dimitra and Batrinou, Anthimia and and Kanellou, Anastasia and Strati, Irini F. and Siatelis, Argyris and and Halvatsiotis, Panagiotis",
    journal = "Gene and Gene Editing",
    year = "2022",
    volume = "13",
    number = "1",
    publisher = "MDPI",
    issn = "2376-3949, 2376-3957",
    doi = "10.3390/genes13010059",
    keywords = "<p>TNF-alpha-308G/A</p>; type 2 diabetes mellitus; polymorphism; leptin
receptor gene (LEPR) Gln223Arg",
    abstract = "The objective of the present study was to identify the association of
the TNF-alpha- 308G/A and leptin receptor (LEPR) Gln223Arg polymorphisms
with the risk of development of type 2 diabetes mellitus (T2DM).
Methods: A total of 160 volunteers were studied: 108 with T2DM and 52
participants as control, who served as the control group. Polymerase
chain reaction-restriction fragment length polymorphism (PCR-RFLP) for
the genomic region of TNF-alpha- 308G/A and LEPR Gln223Arg were carried
out. Results: The frequency of LEPR Gln223Arg genotypes in T2DM and
control groups showed significant differences in the distribution of
genotypes (p < 0.05). The frequency also of TNF-alpha- 308G/A genotypes
in T2DM and control subjects showed significant differences in the
distribution of genotypes (p < 0.05). Conclusion: Our results indicate
that there are significant differences in the distribution of genotypes
and alleles between the individuals with T2DM and control subjects (p <
0.05)."
}