@article{3033878,
    title = "p A snapshot of exhaled nitric oxide and asthma characteristics:
experience from high to low income countries",
    author = "Pignatti, Patrizia and Visca, Dina and Loukides, Stelios and Martson, and Anne -Grete and Alffenaar, Jan-Willem C. and Migliori, Giovanni Battista and and Spanevello, Antonio",
    journal = "ISRN Pulmonology",
    year = "2022",
    volume = "28",
    number = "1",
    pages = "44-58",
    publisher = "Elsevier",
    issn = "2090-5777",
    doi = "10.1016/j.pulmoe.2020.10.016",
    keywords = "Airway inflammation; FeNO; Rehabilitation; Comorbidities; Therapy",
    abstract = "Nitric oxide is a gas produced in the airways of asthmatic subjects and
related to T2 inflammation. It can be measured as fractional nitric
oxide (FeNO) in the exhaled air and used as a non-invasive, easy to
evaluate, rapid marker. It is now widely used in many settings to
determine airway inflammation. The aim of this narrative review is to
report relationship between FeNO and the physiopathologic
characteristics of asthmatic patients. Factors affecting FeNO levels
have also been analysed as well as the impact of corticosteroid, target
therapies and rehabilitation programs. Considering the availability of
the test, spreading this method-ology to low income countries has also
been considered as a possibility for evaluating airway inflammation and
monitoring adherence to inhaled corticosteroid therapy. PubMed data
search has been performed restricted to English language papers.
Research was limited to studies in adults unless studies in children
were the only ones reported for a particular issue. This revision could
be useful to summarize the role of FeNO in relation to asthma
charac-teristics and help in the use of FeNO in different clinical
settings particularly in low income countries. (c) 2020 Sociedade
Portuguesa de Pneumologia. Published by Elsevier Espana, S.L.U. This is
an open access article under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/)."
}