@article{3033913,
    title = "Systematic Review and Meta-analysis of Histological Gastric Biopsy
Aspects According to the Updated Sydney System in Children",
    author = "Kalach, Nicolas and Zrinjka, Misak and Bontems, Patrick and Kori, Michal and and Homan, Matjaz and Cabral, Jose and Casswall, Thomas and Chong, Sonny and and Cilleruelo, Maria Luz and Faraci, Simona and Megraud, Francis and and Papadopoulou, Alexandra and Pehlivanoglu, Ender and Raymond, Josette and and Rea, Francesca and Maria, Rogalidou and Roma, Eleftheria and Tavares, and Marta and Ugras, Meltem and Urbonas, Vaidotas and Urruzuno, Pedro and and Gosset, Pierre and Creusy, Colette and Delebarre, Mathilde and Verdun, and Stephane and ESPGHAN-Helicobacter Pylori Specia",
    journal = "Journal of Pediatric Gastroenterology and Nutrition,",
    year = "2022",
    volume = "74",
    number = "1",
    pages = "13-19",
    publisher = "Lippincott, Williams & Wilkins",
    issn = "0277-2116",
    doi = "10.1097/MPG.0000000000003259",
    keywords = "activity; atrophy; children; gastritis; Helicobacter pylori; intestinal
metaplasia; Sydney classification",
    abstract = "Objectives: A descriptive and comparative study of gastric histological
aspects according to the updated Sydney classification (USC), obtained
from Helicobacter pylori-positive versus H pylori-negative children
referred for upper gastrointestinal endoscopy. Methods: The Prisma
method was used to perform a systematic review and meta-analysis.
Selection criteria were based on following key words USC, H pylori,
children, endoscopy, or biopsy. Publication biases were assessed
according to the Newcastle-Ottawa Scale, and a meta-regression analysis
was done. The study was registered on the PROSPERO platform. Results:
Between 1994 and 2017, 1238 references were found; 97 studies were
retained for the systematic review with a total number of 25,867
children; 75 studies were selected for the meta-analysis concerning 5990
H pylori-infected and 17,782 uninfected children. H pylori-positive
versus H pylori-negative children, according to the USC, showed
significantly higher relative risk for gastric antral and corpus chronic
inflammation, presence of neutrophils, and of lymphoid follicles, and
gastric mucosa atrophy, whereas, intestinal metaplasia showed a
significantly higher RR only in antral biopsies. The meta-regression
analysis showed that H pylori-positive versus H pylori-negative children
had significantly higher risk only for corpus activity according to age,
recurrent abdominal pain, and geographical area of low H pylori
prevalence. Conclusions: H pylori infection in children was associated
with higher relative risk for gastric antral and corpus chronic
inflammation, presence of neutrophils, lymphoid follicles, and rare
gastric mucosa atrophy, whereas, rare intestinal metaplasia was only
significantly higher in the antral area."
}