@article{3034719,
    title = "Megaprosthesis anti-bacterial coatings: A comprehensive translational
review",
    author = "Lex, Johnathan R. and Koucheki, Robert and Stavropoulos, Nikolaos A. and and Di Michele, Joseph and Toor, Jay S. and Tsoi, Kim and Ferguson, Peter C. and and Turcotte, Robert E. and Papagelopoulos, Panayiotis J.",
    journal = "Acta Biomaterialia",
    year = "2022",
    volume = "140",
    pages = "136-148",
    publisher = "Elsevier Sci Ltd, Exeter, United Kingdom",
    issn = "1742-7061",
    doi = "10.1016/j.actbio.2021.11.045",
    keywords = "Periprosthetic joint infection; Implant coating; Prevention; Orthopaedic
oncology; Joint replacement; Bacterial biofilm; Orthopaedic surgery",
    abstract = "Periprosthetic joint infections (PJI) are catastrophic complications for
patients with implanted megaprostheses and pose significant challenges
in the management of orthopaedic oncology patients. Despite various
preventative strategies, with the increasing rate of implanted
orthopaedic prostheses, the number of PJIs may be increasing. PJIs are
associated with a high rate of amputation. Therefore, novel strategies
to combat bacterial colonization and biofilm formation are required. A
promising strategy is the utilization of anti-bacterial coatings on
megaprosthetic implants. In this translational review, a brief overview
of the mechanism of bacterial colonization of implants and biofilm
formation will be provided, followed by a discussion and classification
of major anti-bacterial coatings currently in use and development. In
addition, current in vitro outcomes, clinical significance, economic
importance, evolutionary perspectives, and future directions of
anti-bacterial coatings will also be discussed. Megaprosthetic
anti-bacterial coating strategies will help reduce infection rates
following the implantation of megaprostheses and would positively impact
sarcoma care."
}