@article{3045132, title = "SOLID-PHASE SYNTHESIS OF A SOMATOSTATIN AMIDE ANALOG USING ACID LABILE TERT-BUMEOC PROTECTION AND AN ACID LABILE ANCHOR GROUP", author = "VOELTER, W and BREIPOHL, G and TZOUGRAKI, C and JUNGFLEISCHTURGUT, E", journal = "Collection of Czechoslovak Chemical Communications", year = "1992", volume = "57", number = "8", pages = "1707-1718", publisher = "INST ORGANIC CHEM AND BIOCHEM", issn = "0010-0765, 1212-6950", doi = "10.1135/cccc19921707", abstract = "The solid phase synthesis of an amidated somatostatin analogue based on the principle of differentiated acidolysis is described. The acid labile and smoothly cleavable t-Bumeoc moiety (1% TFA/DCM) is used for temporary N(alpha)-protection of D- and L-amino acids and [4-[[[9H-fluoren-9-yl-methoxycarbonyl]amino](4-methoxyphenyl)met hyl]-2-methylphenoxy]acetic acid, attached to an aminomethylated polystyrene resin is used as acid sensitive linker of the solid carrier which releases the peptide in its amide form by treatment with TFA. Its preparation is described in detail." }