@article{3047369,
    title = "THE PRODUCTION OF PLATELET-ACTIVATING-FACTOR (PAF) DURING HEMODIALYSIS
WITH CUPROPHANE MEMBRANE - DOES THE CALCIUM-CONCENTRATION IN THE
DIALYSATE PLAY ANY ROLE ON IT",
    author = "IATROU, C and AFENTAKIS, N and ANTONOPOULOU, S and ANDRIKOPOULOS, N and and DEMOPOULOS, CA and ZIROYANNIS, P",
    journal = "The International Journal of Artificial Organs",
    year = "1995",
    volume = "18",
    number = "7",
    pages = "355-361",
    publisher = "Wichtig Editore",
    doi = "10.1177/039139889501800702",
    keywords = "PLATELET-ACTIVATING; FACTOR; PAF; HEMODIALYSIS; DIALYSATE;
BIOCOMPATIBILITY",
    abstract = "There is evidence that PAF may be produced during hemodialysis (HD)
mainly when using cuprophane membrane (CU). It is also known that PAF
production is dependent on the amount of extracellular calcium
(E(Ca)(2+)). In the present study, we investigated the production of PAF
during HD with CU as well as the role of the Ca2+ in the dialysate with
respect to PAF production. Five hemodialyzed patients were studied in
two consecutive HD sessions (the first performed using dialysate without
Ca2+. and the second with a Ca2+ concentration of 3.25 mEq/L) and at
different times during the sessions the circulating PAF levels as well
as the leukocyte and platelet counts were measured. The results
demonstrated that a) PAF was indeed produced during HD with CU, b) the
highest PAF levels in blood were observed between 5 and 15 minutes from
the beginning of HD, at which time the lowest circulating leukocyte and
platelet count were measured and c) PAF levels in blood were inversely
proportional to the Ca2+ concentration in the dialysate (with the
exceptional case of the 15 minutes), although we expected the opposite
results."
}