@article{3049537,
    title = "Evidence that adult life risk factors influence the expression of
familial propensity to breast cancer",
    author = "Katsouyanni, K and Signorello, LB and Lagiou, P and Egan, K and and Trichopoulos, D",
    journal = "Epidemiology Monitor",
    year = "1997",
    volume = "8",
    number = "5",
    pages = "592-595",
    publisher = "Lippincott, Williams & Wilkins",
    doi = "10.1097/00001648-199709000-00019",
    keywords = "familial breast cancer; risk factors; interaction; case control study",
    abstract = "In the context of a study in Athens comprising 692 cases and 1,261
controls, we have evaluated the effect on breast cancer risk of the
joint action of first-degree relative family history and established
adult life risk factors. We created a risk score by assigning the value
of 1 to women at high risk with respect to any of these risk factors and
0 otherwise, and summing these values, using weights equal to the excess
odds ratio. The odds ratio for a tertile increment in the risk score was
1.5 [95% confidence interval (CI) = 1.3-1.8] among women without
family history, and 2.3 (95% CI = 1.1-5.1) for women with family
history. Our findings imply that women with a family history of breast
cancer may benefit disproportionately by reduced exposure to adult life
risk factors."
}