@article{3050793,
    title = "Comparative in vitro and in vivo efficacy of roxithromycin and
erythromycin against a strain of methicillin-susceptible Staphylococcus
epidermidis",
    author = "Danias, PG and Chalevelakis, G and Mylonakis, EE and Argyropoulou, A and and Paniara, O and Saroglou, G and Raptis, SA",
    journal = "Diagnostic Microbiology and Infectious Disease",
    year = "1998",
    volume = "32",
    number = "1",
    pages = "51-54",
    publisher = "EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC",
    issn = "0732-8893",
    doi = "10.1016/S0732-8893(98)00059-5",
    abstract = "The in vitro and in vivo efficacy of roxithromycin was compared with
that of erythromycin, against a methicillin-susceptible strain of
Staphylococcus epidermidis. We performed standard in vitro testing (MIC,
MBC, and time-kill kinetics) for roxithromycin, erythromycin, and
rifampin. Both macrolides were bacteriostatic in vitro. There was no
significant difference in microbial survival between erythromycin and
roxithromycin groups in the time-kill kinetics (p = 0.3). For the in
vivo experiments, using the rabbit experimental endocarditis model,
roxithromycin was found to be inferior to erythromycin in decreasing the
microbial burden of the endocardial vegetations (p < 0.05). Rifampin was
highly effective, both in vitro and in vivo. In conclusion, the efficacy
of roxithromycin was poor and inferior to erythromycin against a strain
of methicillin-susceptible S. epidermidis. (C) 1998 Elsevier Science
Inc."
}