@article{3051438,
    title = "Double biochemical modulation of 5-fluorouracil by methotrexate and
folinic acid for the treatment of advanced colorectal cancer",
    author = "Polyzos, A and Tsavaris, N and Kosmas, C and Petrikos, G and and Stamatiadis, D and Kalahanis, N and Giannopoulos, A and Karatzas, G and and Sfikakis, PP",
    journal = "Clinical Drug Investigation",
    year = "1999",
    volume = "17",
    number = "2",
    pages = "83-88",
    publisher = "Adis International Ltd",
    issn = "1173-2563",
    doi = "10.2165/00044011-199917020-00001",
    abstract = "Objective: We investigated the double biochemical modulation of
5-fluorouracil (5-FU) by methotrexate (MTX) and folinic acid (FA) for
the treatment of 65 patients with advanced colorectal cancer. In
particular, we studied the response and toxicity of the regimen.
Methods: A combination of MTX 130 mg/m(2) intravenously at day 0,
followed 24 hours later by FA orally as MTX rescue, and FA 300 mg/m2
intravenously daily (days 1 to 4) followed by 5-FU 500 mg/m(2)
intravenously daily (days 1 to 4) was administered.
Results: Objective response was achieved by 23 patients, with three
complete and 20 partial responses [35%: 95% confidence interval (CI)
23 to 48%]. Median survival of the group was 12 months (range 6 to 36
months).
Conclusion: According to these results, double biochemical modulation of
5-FU : with MTX and FA led to a significantly higher response rate
followed by considerable toxicity."
}