@article{3051839,
    title = "Predictive factors and prevalence of follicular gastritis in adults with
peptic ulcer and nonulcer dyspepsia",
    author = "Ladas, SD and Rokkas, T and Georgopoulos, S and Kitsanta, P and Liatsos, and C and Eustathiadou, P and Karameris, A and Spiliadi, C and Raptis, SA",
    journal = "Digestive Diseases and Sciences",
    year = "1999",
    volume = "44",
    number = "6",
    pages = "1156-1160",
    publisher = "KLUWER ACADEMIC/PLENUM PUBL",
    issn = "0163-2116, 1573-2568",
    doi = "10.1023/A:1026624206987",
    keywords = "follicular gastritis; Helicobacter pylori; duodenal ulcer; gastric
ulcer; nonulcer dyspepsia; MALT lymphoma",
    abstract = "Follicular gastritis is an important histological entity, because it may
progress to overt gastric MALT lymphoma. However, there is no universal
agreement on whether there is any correlation of follicular gastritis
with histological features of the antral mucosa or on the prevalence of
follicular gastritis. To shed further light on these issues, we studied
antral biopsies obtained from 735 adult patients, who had participated
in six consecutive clinical trials, They included 348 patients with
duodenal ulcer, 82 with gastric ulcer, and 305 with nonulcer dyspepsia,
The Sydney classification system of gastritis was used, using a score of
0-3 to grade degree and activity of inflammation, gland atrophy,
intestinal metaplasia, and H. pylori colonization density. Follicular
gastritis was defined as prominent lymphoid follicles with no
lymphoepithelial lesion. None of the H. pylori-negative patients (N =
159) had follicular gastritis. Among H. pylori-positive patients, 80/340
(23.5%) with duodenal ulcer, 5/77 (6.5%) with gastric ulcer, and
20/159 (12.6%) with nonulcer dyspepsia had follicular gastritis (P <
0.001). Multivariate discriminant analysis selected the following four
significant predictor variables for follicular gastritis (Wilks lambda =
0.91, x(2) 70.6, df = 4, P < 0.001): gastritis sum score, atrophic
gastritis, age of the patient, and disease. The prevalence of follicular
gastritis was linearly correlated (y = 24.55 - 0.98x, r = -0.62,
F-1,F-11 = 6.12, P 0.03) with the age groups of the 576 H.
pylori-positive patients studied. In conclusion, follicular gastritis is
highly correlated with H. pylori-caused severe, active gastritis, It is
mostly prevalent in the young H. pylori-infected patients with duodenal
ulcer."
}