@article{3052926,
    title = "Acute promyelocytic leukemia relapsing into FAB-M2 acute myeloid
leukemia with trisomy 8",
    author = "Stavroyianni, N and Yataganas, X and Abazis, D and Pangalos, C and and Meletis, J",
    journal = "CANCER GENETICS AND CYTOGENETICS",
    year = "2000",
    volume = "117",
    number = "1",
    pages = "82-83",
    publisher = "EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC",
    issn = "0165-4608",
    doi = "10.1016/S0165-4608(99)00132-6",
    abstract = "Acute promyelocytic leukemia was diagnosed in a 48-year-old man; the
karyotype was normal, whereas reverse transcriptase polymerase chain
reaction (RT-PCR) analysis identified PML/RAR alpha chimeric transcripts
of the bcr3 type. Rather unexpectedly, the patient did not respond to
all-trans retinoic acid administration; he attained complete remission
with conventional chemotherapy and became PML/RAR alpha negative. Two
years later while PML/RAR alpha negative nn RT-PCR he presented with
thrombocytopenia. Bone marrow examination was compatible with
myelodysplasia of the RAEB type; the karyotype was normal. Then, after
10 months, he developed overt acute myeloid leukemia with PML/RAR alpha
negative, French-American-British MZ blasts; karyotypic analysis
revealed mosaicism for trisomy 8. (C) Elsevier Science Inc., 2000. All
rights reserved."
}