@article{3053138,
    title = "Prediction of restenosis after coronary angioplasty by use of a new
index - TIMI frame count/minimal luminal diameter ratio",
    author = "Stankovic, G and Manginas, A and Voudris, V and Pavlides, G and and Athanassopoulos, G and Ostojic, M and Cokkinos, DV",
    journal = "CIRCULATION",
    year = "2000",
    volume = "101",
    number = "9",
    pages = "962-968",
    publisher = "Lippincott, Williams & Wilkins",
    issn = "0009-7322",
    doi = "10.1161/01.CIR.101.9.962",
    keywords = "angioplasty; blood flow; restenosis; coronary disease",
    abstract = "Background-It has been shown recently that postangioplasty coronary flow
reserve and the degree of residual stenosis have a modest predictive
value for short- and long-term clinical outcomes after coronary
angioplasty. Corrected TIMI frame count (CTFC) is a simple quantitative
index of coronary blood flow. Its relationship with Doppler coronary now
velocity and clinical outcome after coronary angioplasty has not been
fully clarified. The aim of this study was to identify clinical,
angiographic, and functional predictors of clinical and angiographic
restenosis after conventional coronary angioplasty.
Methods and Results-We studied 70 consecutive patients in whom
intracoronary Doppler flow-velocity measurements were performed before
and after angioplasty. Patients were evaluated for restenosis by
clinical follow-up, exercise stress test/Tl-201 scintigraphy, and
follow-up angiography, which was performed at 10.5 +/- 10.3 months in 63
patients. According to the results of univariate analysis, a new index,
postangioplasty CTFC/minimal luminal diameter (MLD) ratio, was created.
Multivariate analysis revealed that CTFC/MLD ratio was the only
independent predictor of angiographic (OR 2.02; 95% CI 1.37 to 2.97;
P<0.0004) and clinical (OR 1.60; 95% CI 1.15 to 2.21; P<0.005)
restenosis, The receiver operating characteristic curve area of this
index was 79% for angiographic and 73% for clinical restenosis. The
optimal CTFC/MLD ratio cutoff values were 7.88 for angiographic and 7.94
for clinical restenosis, respectively.
Conclusions-Our data indicate that postangioplasty CTFC/MLD ratio, which
incorporates both the angiographic and functional features of coronary
lesions, is a reliable, objective, and inexpensive index for prediction
of angiographic and clinical restenosis after conventional coronary
angioplasty."
}