@article{3053232,
    title = "Linkage of mood disorders with D2, D3 and TH genes: a multicenter study",
    author = "Serretti, A and Macciardi, F and Cusin, C and Lattuada, E and Souery, D and and Lipp, O and Mahieu, B and Van Broeckhoven, C and Blackwood, D and and Muir, W and Aschauer, HN and Heiden, AM and Ackenheil, M and Fuchshuber, and S and Raeymaekers, P and Verheyen, G and Kaneva, R and Jablensky, A and and Papadimitriou, GN and Dikeos, DG and Stefanis, CN and Smeraldi, E and and Mendlewicz, J",
    journal = "Journal of Affective Disorders",
    year = "2000",
    volume = "58",
    number = "1",
    pages = "51-61",
    publisher = "ELSEVIER SCIENCE BV",
    issn = "0165-0327",
    doi = "10.1016/S0165-0327(99)00112-3",
    keywords = "dopamine receptors; DRD2; DRD3; tyrosine hydroxylase; linkage; bipolar
disorder",
    abstract = "Background: It has been suggested that the dopaminergic system is
involved in the pathophysiology of mood disorders. We conducted a
multicenter study of families with mood disorders, to investigate a
possible linkage with genes coding for dopamine receptor D2, dopamine
receptor D3 and tyrosine hydroxylase (TH). Methods: Twenty three mood
disorder pedigrees collected within the framework of the European
Collaborative Project on Affective Disorders were analyzed with
parametric and non-parametric linkage methods. Various potential
phenotypes were considered, from a narrow (only bipolar as affected) to
a broad (bipolar + major depressive + schizoaffective disorders)
definition of affection status. Results: Parametric analyses excluded
linkage for all the candidate genes, even though small positive LOD
(Limit of Detection) scores were observed for TH in three families.
Non-parametric analyses yielded negative results for all markers.
Conclusion: The D2 and D3 dopamine receptors were, therefore, not a
major liability factor for mood disorders in our sample, whereas TH may
play a role in a subgroup of patients. (C) 2000 Elsevier Science B.V.
All rights reserved."
}