@article{3058222,
    title = "Physical activity and lung cancer among non-smokers: A pilot molecular epidemiological study within EPIC",
    author = "Rundle, A. and Richie, J. and Steindorf, K. and Peluso, M. and Overvad, K. and Raaschou-Nielsen, O. and Clavel-Chapelon, F. and Linseisen, J.P. and Boeing, H. and Trichopoulou, A. and Palli, D. and Krogh, V. and Tumino, R. and Panico, S. and Bueno-De-Mesquita, H.B. and Peeters, P.H. and Lund, E. and Gonzalez, C.A. and Martinez, C. and Dorronsoro, M. and Barricarte, A. and Tormo, M.J. and Quiros, J.R. and Agudo, A. and Berglund, G. and Jarvholm, B. and Bingham, S. and Key, T.J. and Gormally, E. and Saracci, R. and Kaaks, R. and Riboli, E. and Vineis, P.",
    journal = "Biomarker Insights",
    year = "2010",
    volume = "15",
    number = "1",
    pages = "20-30",
    issn = "1177-2719",
    doi = "10.3109/13547500903186452",
    keywords = "biological marker;  glutathione;  hemoglobin;  phosphorus 32, adult;  aged;  article;  cancer risk;  controlled study;  DNA adduct;  erythrocyte;  female;  human;  leukocyte;  lung cancer;  major clinical study;  male;  molecular epidemiology;  physical activity;  smoking, Aged;  Biological Markers;  Case-Control Studies;  DNA Adducts;  Erythrocytes;  Europe;  Female;  Glutathione;  Humans;  Leukocytes;  Lung Neoplasms;  Male;  Middle Aged;  Molecular Epidemiology;  Motor Activity;  Pilot Projects;  Risk Factors;  Smoking",
    abstract = "The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by 32P-post- labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.350.90), higher GSH levels (1.87 μmol GSH g-1 haemoglobin, p 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.382.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.841.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels. © 2010 Informa UK Ltd."
}