@article{3060965,
    title = "The effects of nitroglycerin during cardiopulmonary resuscitation",
    author = "Stefaniotou, A. and Varvarousi, G. and Varvarousis, D.P. and Xanthos, T.",
    journal = "European Journal of Pharmacology",
    year = "2014",
    volume = "734",
    number = "1",
    pages = "42-49",
    publisher = "Elsevier B.V.",
    issn = "0014-2999",
    doi = "10.1016/j.ejphar.2014.04.002",
    keywords = "adrenalin;  glyceryl trinitrate;  vasopressin;  glyceryl trinitrate;  neuroprotective agent;  vasoconstrictor agent, coronary artery blood flow;  dose response;  drug effect;  drug efficacy;  drug megadose;  drug potency;  heart arrest;  heart protection;  human;  low drug dose;  microvasculature;  neuroprotection;  neurotoxicity;  nonhuman;  pathophysiology;  priority journal;  reperfusion injury;  resuscitation;  review;  survival rate;  treatment outcome;  animal;  procedures;  reperfusion injury;  resuscitation, Animals;  Cardiopulmonary Resuscitation;  Humans;  Neuroprotective Agents;  Nitroglycerin;  Reperfusion Injury;  Vasoconstrictor Agents",
    abstract = "The outcome for both in-hospital and out-of hospital cardiac arrest remains dismal. Vasopressors are used to increase coronary perfusion pressure and thus facilitate return of spontaneous circulation during cardiopulmonary resuscitation. However, they are associated with a number of potential adverse effects and may decrease endocardial and cerebral organ blood flow. Nitroglycerin has a favourable haemodynamic profile which promotes forward blood flow. Several studies suggest that combined use of nitroglycerin with vasopressors during resuscitation, is associated with increased rates of resuscitation and improved post-resuscitation outcome. This article reviews the effects of nitroglycerin during cardiopulmonary resuscitation and postresuscitation period, as well as the beneficial outcomes of a combination regimen consisting of a vasopressor and a vasodilator, such as nitroglycerin. © 2014 Elsevier B.V. All rights reserved."
}