@article{3061828,
    title = "Influence of an additional amino group on the potency of aminoadamantanes against influenza virus A. II - Synthesis of spiropiperazines and in vitro activity against influenza A H3N2 virus",
    author = "Fytas, C. and Kolocouris, A. and Fytas, G. and Zoidis, G. and Valmas, C. and Basler, C.F.",
    journal = "Bioorganic Chemistry",
    year = "2010",
    volume = "38",
    number = "6",
    pages = "247-251",
    issn = "0045-2068, 1090-2120",
    doi = "10.1016/j.bioorg.2010.09.001",
    keywords = "1 methylspiro[piperazine 2,2 tricyclo[3.3.1.1]decane];  1,4 dimethylspiro[piperazine 2,2 tricyclo[3.3.1.1]decane];  amantadine;  amantadine derivative;  amine;  antivirus agent;  heterocyclic compound;  receptor;  spiro[piperidine 2,2 tricyclo[3.3.1.1]decane];  unclassified drug, animal cell;  antiviral activity;  article;  chemical modification;  controlled study;  drug potency;  hydrogen bond;  in vitro study;  Influenza virus A H3N2;  nonhuman;  priority journal, Adamantane;  Animals;  Antiviral Agents;  Cell Line;  Humans;  Influenza A Virus, H3N2 Subtype;  Influenza, Human;  Orthomyxoviridae Infections;  Piperazines;  Spiro Compounds, Influenza A virus;  Orthomyxoviridae",
    abstract = "Spiro[piperidine-2,2′-adamantane] 4 is one of the most potent synthetic anti-influenza A aminoadamantanes or other cage structure amines tested so far. Based on previous results Tataridis et al. (2007) [5h] which demonstrate the boost of in vitro potency by the presence of an additional amino group, we examined whether the incorporation of a second amino group into this heterocycle would increase the anti-influenza A virus activity. The new synthetic molecules 5-7 are capable of forming two hydrogen bonds within the receptor. We identified the diamino derivatives 5 and 6, which are active against influenza A H3N2 virus although less potent than amantadine and its equipotent spiropiperidine 4. © 2010 Elsevier Inc. All rights reserved."
}