@article{3062177,
    title = "Antidepressants influence somatostatin levels and receptor pharmacology in brain",
    author = "Pallis, E. and Vasilaki, A. and Fehlmann, D. and Kastellakis, A. and Hoyer, D. and Spyraki, C. and Thermos, K.",
    journal = "European Neuropsychopharmacology",
    year = "2009",
    volume = "34",
    number = "4",
    pages = "952-963",
    issn = "0924-977X",
    doi = "10.1038/npp.2008.133",
    keywords = "citalopram;  desipramine;  somatostatin;  somatostatin receptor, animal experiment;  animal tissue;  article;  autoradiography;  caudate nucleus;  controlled study;  drug receptor binding;  frontal cortex;  hippocampus;  male;  nonhuman;  nucleus accumbens;  prefrontal cortex;  priority journal;  putamen;  radioimmunoassay;  rat;  receptor density, Analysis of Variance;  Animals;  Antidepressive Agents;  Autoradiography;  Brain;  Citalopram;  Desipramine;  Immunoassay;  Iodine Radioisotopes;  Male;  Octreotide;  Peptides, Cyclic;  Rats;  Rats, Sprague-Dawley;  Receptors, Somatostatin;  Somatostatin",
    abstract = "This study investigated how the administration (acute and chronic) of the antidepressants citalopram and desmethylimipramine (DMI) influences somatostatin (somatotropin release inhibitory factor, SRIF) levels and SRIF receptor density (sst1-5) in rat brain. Animals received either of the following treatments: (1) saline for 21 days (control group), (2) saline for 20 days and citalopram or DMI for 1 day (citalopram or DMI acute groups), (3) citalopram or DMI for 21 days (citalopram or DMI chronic groups). Somatostatin levels were determined by radioimmunoassay. [125I]LTT SRIF-28 binding in the absence (labeling of sst1-5) or presence of 3 nM MK678 (labeling of sst1/4) and [125I]Tyr3 octreotide (labeling of sst2/5) binding with subsequent autoradiography was performed in brains of rats treated with both antidepressants. Somatostatin levels were increased after citalopram, but not DMI administration, in the caudate-putamen, hippocampus, nucleus accumbens, and prefrontal cortex. Autoradiography studies illustrated a significant decrease in receptor density in the superficial and deep layers of frontal cortex (sst2), as well as a significant increase in the CA1 (sst1/4) hippocampal field in brains of chronically citalopram-treated animals. DMI administration increased sst 1/4 receptors levels in the CA1 hippocampal region. These results suggest that citalopram and to a lesser extent DMI influence the function of the somatostatin system in brain regions involved in the emotional, motivational, and cognitive aspects of behavior. © 2009 Nature Publishing Group All rights reserved."
}