@article{3062356,
    title = "Effect of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-α levels in rats",
    author = "Trapali, M. and Liapi, C. and Perelas, A. and Perrea, D. and Stroubini, T. and Dontas, I. and Couvari, E. and Mavri, M. and Galanopoulou, P.",
    journal = "Pharmacological Research Communications",
    year = "2008",
    volume = "82",
    number = "1",
    pages = "15-21",
    doi = "10.1159/000127363",
    keywords = "sibutramine;  tumor necrosis factor alpha, animal experiment;  article;  body mass;  body weight;  caloric intake;  carbohydrate diet;  controlled study;  drug effect;  food intake;  lipid diet;  male;  nonhuman;  priority journal;  protein diet;  rat;  weight gain, Animals;  Appetite Depressants;  Body Weight;  Cyclobutanes;  Diet;  Dietary Carbohydrates;  Dietary Fats;  Dietary Proteins;  Eating;  Energy Intake;  Enzyme-Linked Immunosorbent Assay;  Feeding Behavior;  Male;  Rats;  Rats, Wistar;  Tumor Necrosis Factor-alpha;  Weight Gain",
    abstract = "Background/Aim: The effect of isocaloric diets and sibutramine on dietary behaviour and TNF-α is poorly understood. The aim of the study was to investigate the effects of isocaloric diets and sibutramine on food intake, body mass variation and serum TNF-α in free-feeding rats. Methods: Three groups of male Wistar rats (n = 63) were fed a high-fat diet, high-carbohydrate diet or high-protein diet for 13 weeks. In the last 3 weeks, each group was divided into 3 subgroups. Each subgroup received sibutramine 5 mg/kg, sibutramine 10 mg/kg or vehicle. Food intake was measured daily during the last week of the experiment; serum TNF-α was assayed and the body weight increasing rate was calculated. Results: The high-fat diet was associated with increased food intake, a greater weight gain ratio and increased TNF-α levels. Sibutramine treatment did not affect the dietary behaviour of high-protein- or high-carbohydrate-fed rats, while it significantly attenuated the daily food intake and body weight gain rate in the high-fat group, at the dose of 10 mg/kg. TNF-α levels were not affected by sibutramine. Conclusions: High-fat feeding was associated with an increase in daily food intake, TNF-α levels and body weight gain rate, as well as with enhanced responsiveness to the anorectic effects of sibutramine. However, sibutramine did not affect TNF-α. Copyright © 2008 S. Karger AG."
}