@article{3062501,
    title = "A simple method for the alkaline hydrolysis of esters",
    author = "Theodorou, V. and Skobridis, K. and Tzakos, A.G. and Ragoussis, V.",
    journal = "TETRAHEDRON LETTERS",
    year = "2007",
    volume = "48",
    number = "46",
    pages = "8230-8233",
    issn = "0040-4039",
    doi = "10.1016/j.tetlet.2007.09.074",
    keywords = "alcohol derivative;  carboxylic acid;  dichloromethane;  ester;  ester derivative;  methanol;  sodium hydroxide;  solvent, alkalinity;  article;  drug synthesis;  hydrolysis;  nonaqueous phase liquid;  organic chemistry;  process development;  reaction analysis;  room temperature;  saponification;  stereochemistry;  temperature dependence",
    abstract = "A very mild and rapid procedure for the efficient alkaline hydrolysis of esters in non-aqueous conditions has been developed, by the use of dichloromethane/methanol (9:1) as solvent. This method conveniently provides both carboxylic acids and alcohols from the corresponding esters and sodium hydroxide in a few minutes at room temperature. A plausible reaction mechanism is proposed. © 2007 Elsevier Ltd. All rights reserved."
}