@article{3062571,
    title = "Synthesis of novel nitro-substituted triaryl pyrazole derivatives as potential estrogen receptor ligands",
    author = "Naoum, F. and Kasiotis, K.M. and Magiatis, P. and Haroutounian, S.A.",
    journal = "Molecules (Basel, Switzerland)",
    year = "2007",
    volume = "12",
    number = "7",
    pages = "1259-1273",
    doi = "10.3390/12071259",
    keywords = "estrogen receptor alpha;  estrogen receptor beta;  ligand;  nitro derivative;  pyrazole;  pyrazole derivative, article;  chemistry;  human;  metabolism;  synthesis, Estrogen Receptor alpha;  Estrogen Receptor beta;  Humans;  Ligands;  Nitro Compounds;  Pyrazoles",
    abstract = "Novel tetrasubstituted pyrazole derivatives bearing a nitro substituent on their A-phenol ring were synthesized and their binding affinity towards the estrogen receptor (ER) subtypes ERα and ERβ was determined. Among compounds tested, the 2-nitrophenol derivative 5c was found to bind satisfactorily to both estrogen receptor subtypes (RBAα=5.17 and RBAβ=3.27). In general, the introduction of a nitro group into the A ring of these compounds was found to benefit their ERβ binding abilities. © 2007 by MDPI."
}