@article{3062711,
    title = "Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties",
    author = "Siskou, I.C. and Rekka, E.A. and Kourounakis, A.P. and Chrysselis, M.C. and Tsiakitzis, K. and Kourounakis, P.N.",
    journal = "BIOORGANIC AND MEDICINAL CHEMISTRY",
    year = "2007",
    volume = "15",
    number = "2",
    pages = "951-961",
    issn = "0968-0896",
    doi = "10.1016/j.bmc.2006.10.056",
    keywords = "1 [2 (4 isobutylphenyl)propanoyl] n (2 mercaptoethyl)pyrrolidine 2 carboxamide;  2 methoxy 4 methylphenyl 1 (isobutyryl)pyrrolidine 2 carboxylate;  2 methoxy 4 methylphenyl 1 [2 (4 isobutylphenyl)propanoyl]pyrrolidine 2 carboxylate;  3 (pyridin 3 yl)propyl 1 (isobutyryl)pyrrolidine 2 carboxylate;  3 (pyridin 3 yl)propyl 1 [2 (4 isobutylphenyl)propanoyl]pyrrolidine 2 carboxylate;  acetylcholinesterase;  antioxidant;  cyclooxygenase 2;  ethyl 2 [1 [2 (4 isobutylphenyl)propanoyl]pyrrolidine 2 carboxamido] 3 mercaptopropanoate;  glutathione;  ibuprofen;  ibuprofen derivative;  lipoxygenase, adjuvant arthritis;  animal cell;  animal experiment;  animal model;  animal tissue;  antiinflammatory activity;  arthritis;  article;  brain ischemia;  brain perfusion;  controlled study;  degenerative disease;  drug design;  enzyme synthesis;  gastrointestinal toxicity;  male;  mouse;  neuroprotection;  nonhuman;  paw edema;  rat;  reperfusion injury, Animals;  Antioxidants;  Arthritis, Experimental;  Blood-Brain Barrier;  Cholesterol;  Cholinesterase Inhibitors;  Cyclooxygenase 2 Inhibitors;  Freund's Adjuvant;  Gastrointestinal Diseases;  Glutathione;  Hyperlipidemias;  Hypoxia-Ischemia, Brain;  Ibuprofen;  Lipid Peroxidation;  Lipoxygenase Inhibitors;  Mice;  Microsomes, Liver;  Neuroprotective Agents;  Nootropic Agents;  Oxidative Stress;  Picrates;  Rats;  Spleen;  Triglycerides",
    abstract = "Six novel ibuprofen derivatives and related structures, incorporating a proline moiety and designed for neurodegenerative disorders, are studied. They possess anti-inflammatory properties and three of them inhibited lipoxygenase. One compound was found to inhibit cyclooxygenase (COX)-2 production in spleenocytes from arthritic rats. The HS-containing compounds are potent antioxidants and one of them protected against glutathione loss after cerebral ischemia/reperfusion. They demonstrated lipid-lowering ability and seem to acquire low gastrointestinal toxicity. Acetylcholinesterase inhibitory activity, found in two of these compounds, may be an asset to their actions. © 2006 Elsevier Ltd. All rights reserved."
}