@article{3063059,
    title = "A facile synthesis of C2-substituted pyrrolo[2,3-f]quinolines with cytotoxic activity",
    author = "Tsotinis, A. and Vlachou, M. and Zouroudis, S. and Jeney, A. and Timár, F. and Thurston, D.E. and Roussakis, C.",
    journal = "Letters in Drug Design and Discovery",
    year = "2005",
    volume = "2",
    number = "3",
    pages = "189-192",
    doi = "10.2174/1570180053765075",
    keywords = "1h pyrrolo[2,3 f]quinoline 2 carboxamide derivative;  6 quinolinecarboxaldehyde;  pyrrolo[2,3 f]quinoline derivative;  quinoline derivative;  unclassified drug, article;  cyclization;  cytotoxicity;  drug hydrolysis;  drug structure;  drug synthesis;  priority journal;  tumor cell line",
    abstract = "An expeditious four-step synthesis of the 1H-pyrrolo[2,3-f]quinoline-2- carboxamides (5a-h) is described. Readily available 6-quinolinecarboxaldehyde is converted to the parent acid (6) by nucleophilic attack of the azido-ester (9) and intramolecular cyclization of (10) followed by hydrolysis of the methyl ester (11). The cytotoxicity of the target molecules (5a-h) was evaluated in four tumour cell lines in vitro. One compound (5d) showed sufficient activity (IC50 = 10.2 μM) in the human non-small cell lung cell line NSCLC-N16-L16 to be worthy of further study. © 2005 Bentham Science Publishers Ltd."
}