@article{3063079,
    title = "Synthesis of the marine furanoditerpene (-)-marginatone",
    author = "Kolympadi, M. and Liapis, M. and Ragoussis, V.",
    journal = "Tetrahedron",
    year = "2005",
    volume = "61",
    number = "8",
    pages = "2003-2010",
    issn = "0040-4020",
    doi = "10.1016/j.tet.2005.01.007",
    keywords = "diterpene;  furanoditerpene;  marginatone;  unclassified drug, article;  carbon nuclear magnetic resonance;  chemical reaction;  drug synthesis;  molecular interaction;  oxidation;  priority journal;  proton nuclear magnetic resonance",
    abstract = "A synthesis of the marine labdane furanoditerpene (-)-marginatone 1 has been accomplished by a short sequence of reactions starting from (+)-coronarin E 5. The key step is the stereocontrolled-intramolecular electrophilic cyclisation of the (+)-dihydrocoronarin E 6, to the tetracyclic marginatane skeleton 7, which is subsequently functionalized by allylic oxidation to give 1. As (+)-coronarin E 5 was previously synthesized from (-)-sclareol 10, the herein reported preparation constitutes the first formal total synthesis of (-)-marginatone 1, by which its absolute configuration has been confirmed. © 2005 Elsevier Ltd. All rights reserved."
}